Detailed information of TA system TA042918

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HTH(antitoxin)
• Location: 4524886..4525488
• Replicon: chromosome
• Accession: NZ_AP026948
• Organism: Salmonella enterica strain SE20-72C-2

Toxin (Protein)

• Gene name: higB
• Uniprot ID: A0A3V8XMR3
• Locus tag: OO990_RS22195
• Protein ID: WP_001159631.1
• Coordinates: 4525177..4525488 (-)
• Length: 104 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: OO990_RS22190
• Protein ID: WP_000362050.1
• Coordinates: 4524886..4525176 (-)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
OO990_RS22175 (SE2072C2_42540)	4522379..4523281	+	903	WP_000331364.1	formate dehydrogenase subunit beta	-
OO990_RS22180 (SE2072C2_42550)	4523278..4523913	+	636	WP_000829025.1	formate dehydrogenase cytochrome b556 subunit	-
OO990_RS22185 (SE2072C2_42560)	4523910..4524839	+	930	WP_000027730.1	formate dehydrogenase accessory protein FdhE	-
OO990_RS22190 (SE2072C2_42570)	4524886..4525176	-	291	WP_000362050.1	DNA-binding transcriptional regulator	Antitoxin
OO990_RS22195 (SE2072C2_42580)	4525177..4525488	-	312	WP_001159631.1	cytotoxic translational repressor of toxin-antitoxin stability system	Toxin
OO990_RS22200 (SE2072C2_42590)	4525706..4526635	+	930	WP_001127691.1	alpha/beta hydrolase	-
OO990_RS22205 (SE2072C2_42600)	4526721..4527032	+	312	WP_264878675.1	type II toxin-antitoxin system HigB family toxin	-
OO990_RS22210 (SE2072C2_42610)	4527029..4527475	+	447	WP_001259009.1	type II toxin-antitoxin system HigA family antitoxin	-
OO990_RS22215 (SE2072C2_42620)	4527490..4528431	-	942	WP_001518251.1	fatty acid biosynthesis protein FabY	-
OO990_RS22220 (SE2072C2_42630)	4528476..4528913	-	438	WP_000560974.1	D-aminoacyl-tRNA deacylase	-
OO990_RS22225 (SE2072C2_42640)	4528910..4529782	-	873	WP_000921423.1	virulence factor BrkB family protein	-
OO990_RS22230 (SE2072C2_42650)	4529776..4530375	-	600	WP_000965695.1	glucose-1-phosphatase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Cro/C1-type helix-turn-helix domain (36-85)

Sequences

Toxin

Protein

• Length: 104 a.a.
• Molecular weight: 12312.25 Da
• Isoelectric Point: 9.4460

>T42918 WP_001159631.1 NZ_AP026948:c4525488-4525177 [Salmonella enterica]
MQFIETELFTEDVKKLLDDDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEVRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Nucleotide

• Length: 312 bp

>T42918 NZ_AP026948:c4525488-4525177 [Salmonella enterica]
ATGCAATTCATAGAAACGGAACTCTTTACTGAAGATGTTAAAAAACTGCTCGATGATGATGAATACCATAAGCTTCAGGT
TTTTATGGCTCAGCATCCAGATTGTGGTGATGTCATTCAGGAAACGGGCGGCCTGAGAAAAATGCGCTGGGGAGCGCGAG
GCAAAGGAAAGCGCAGTGGCGTACGAATTATCTATTTTCATCGTAGTCAACGGTATGAGGTTCGCTTGCTTCTGATTTAT
CAAAAAGGCATTAAAGATGATCTCACGCCGCAGGAAAAAGCGGTGCTTCGTATGCTGAATGAGAGGTGGTAG

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10971.59 Da
• Isoelectric Point: 10.6525

>AT42918 WP_000362050.1 NZ_AP026948:c4525176-4524886 [Salmonella enterica]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Nucleotide

• Length: 291 bp

>AT42918 NZ_AP026948:c4525176-4524886 [Salmonella enterica]
ATGGATAAAGTGTTATTTGAGCGATTAACTCAAAGTATGTCTCAAATGAATGAAATCATTGAAGGGACCCGTGAGCCTTC
TCGTACCTTTCATATTGATGCAATGAAGATTAAAGAAATACGGCAGGCATCTGGGTTGTCGCAATCTAAGTTTGCAGAAC
TGATTTCGGTCAACGTGGATACGCTGCGCAACTGGGAGCAAGGAAGACGTTCACCGACAGGGCCAGCCAAAGCGTTACTT
CGCGCCATTGCCAACGACCCGAGAAACGTTATACAAGCATTGCGTTATTGA

Structures

Toxin

• AlphaFold DB: A0A3V8XMR3