Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 88842..89488 Replicon chromosome
Accession NZ_AP026886
Organism Enterobacter asburiae strain KAM576

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag OO861_RS00395 Protein ID WP_182410756.1
Coordinates 89138..89488 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag OO861_RS00390 Protein ID WP_023309874.1
Coordinates 88842..89141 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OO861_RS00365 (KAM576c_00700) 84565..85326 + 762 WP_182410759.1 winged helix-turn-helix domain-containing protein -
OO861_RS00370 (KAM576c_00710) 85328..85807 + 480 WP_023309865.1 hypothetical protein -
OO861_RS00375 (KAM576c_00720) 85997..86935 + 939 WP_182410838.1 helix-turn-helix domain-containing protein -
OO861_RS00380 (KAM576c_00730) 87021..88019 + 999 WP_182410758.1 class I SAM-dependent methyltransferase -
OO861_RS00385 (KAM576c_00740) 88376..88813 + 438 WP_182410757.1 acetyltransferase -
OO861_RS00390 (KAM576c_00750) 88842..89141 - 300 WP_023309874.1 XRE family transcriptional regulator Antitoxin
OO861_RS00395 (KAM576c_00760) 89138..89488 - 351 WP_182410756.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OO861_RS00405 (KAM576c_00770) 90314..91705 + 1392 WP_048980239.1 glycoside-pentoside-hexuronide family transporter -
OO861_RS00410 (KAM576c_00780) 91718..94036 + 2319 WP_182382835.1 alpha-xylosidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-105)

Antitoxin

HigA2-like, helix-turn-helix domain

(12-88)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 13515.63 Da        Isoelectric Point: 8.8449

>T42788 WP_182410756.1 NZ_AP026886:c89488-89138 [Enterobacter asburiae]
MWTVLFGKVFEQWLLEQEEGLQDKVLADLLNLQKYGPRLPRPYADTVKGSRYNHMKELRIQYAGRPIRAFFAFDPVRQAI
VLCAGDKSNDKAFYEKMIRIAEAEFSFHLTSLEATK

Download         Length: 351 bp

>T42788 NZ_AP026886:c89488-89138 [Enterobacter asburiae]
ATGTGGACGGTTCTGTTCGGAAAGGTATTCGAGCAATGGCTGCTTGAACAGGAAGAAGGATTACAGGATAAGGTACTGGC
AGACCTGCTAAATCTGCAAAAATATGGGCCACGTCTTCCACGGCCCTATGCTGATACGGTTAAAGGCTCACGGTATAACC
ATATGAAAGAATTACGTATTCAATATGCTGGACGTCCGATACGTGCTTTCTTCGCATTTGATCCTGTCCGTCAGGCCATT
GTGCTTTGCGCGGGCGATAAGAGTAACGACAAAGCCTTTTATGAAAAAATGATTCGCATCGCAGAAGCAGAATTTTCCTT
CCATCTGACAAGCCTGGAGGCAACCAAGTGA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11165.99 Da        Isoelectric Point: 7.2052

>AT42788 WP_023309874.1 NZ_AP026886:c89141-88842 [Enterobacter asburiae]
VKTLNEVIASRSPESQQRIKEMADEMILETGLQLLREELRLSQKNVADLMGVSQPAVTQLEQRGNELKIATLKRYIEAMG
GKLHIDIELPTGKRVAFHI

Download         Length: 300 bp

>AT42788 NZ_AP026886:c89141-88842 [Enterobacter asburiae]
GTGAAAACCTTAAATGAAGTGATTGCGTCACGTTCACCGGAAAGCCAACAACGTATTAAAGAGATGGCAGATGAAATGAT
CCTCGAGACGGGTCTGCAACTTTTACGTGAAGAGCTGAGACTTTCGCAAAAAAATGTTGCCGATCTGATGGGGGTGAGTC
AGCCCGCAGTGACACAGCTTGAGCAACGTGGAAATGAACTCAAAATTGCCACACTTAAGCGCTACATTGAGGCAATGGGG
GGGAAACTTCATATCGACATTGAACTTCCCACAGGAAAACGCGTTGCATTTCATATCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References