Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 4216756..4217014 Replicon chromosome
Accession NZ_AP026788
Organism Escherichia coli strain IPCEC42

Toxin (Protein)


Gene name hokC Uniprot ID S1NX00
Locus tag OPA56_RS20785 Protein ID WP_000809168.1
Coordinates 4216862..4217014 (+) Length 51 a.a.

Antitoxin (RNA)


Gene name sokC
Locus tag -
Coordinates 4216756..4216813 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OPA56_RS20770 4212585..4213844 - 1260 WP_000494928.1 hypothetical protein -
OPA56_RS20775 4213973..4215466 - 1494 WP_001173016.1 sulfatase-like hydrolase/transferase -
OPA56_RS20780 4215487..4216248 - 762 WP_001274833.1 outer membrane protein OmpK -
- 4216756..4216813 - 58 - - Antitoxin
OPA56_RS20785 4216862..4217014 + 153 WP_000809168.1 type I toxin-antitoxin system toxin MokC Toxin
OPA56_RS20790 4217118..4218248 - 1131 WP_001118464.1 molecular chaperone DnaJ -
OPA56_RS20795 4218337..4220253 - 1917 WP_000516135.1 molecular chaperone DnaK -
OPA56_RS20800 4220624..4221028 + 405 WP_000843689.1 DUF2541 family protein -
OPA56_RS20805 4221054..4221767 + 714 WP_001102393.1 acidic protein MsyB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(6-47)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5501.57 Da        Isoelectric Point: 7.1312

>T42706 WP_000809168.1 NZ_AP026788:4216862-4217014 [Escherichia coli]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Download         Length: 153 bp

>T42706 NZ_AP026788:4216862-4217014 [Escherichia coli]
ATGAAGCAGCATAAGGCGATGATTGTCGCCCTGATCGTCATCTGTATCACCGCCGTAGTGGCGGCGCTGGTAACGAGAAA
AGACCTCTGTGAGGTTCACATCCGAACTGGCCAGACGGAGGTTGCTGTTTTCACGGCTTACGAATCCGAGTAA

Antitoxin


Download         Length: 58 bp

>AT42706 NZ_AP026788:c4216813-4216756 [Escherichia coli]
GTTCTGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1NX00

Antitoxin

Download structure file

References