Detailed information of TA system TA042691

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/YoeB-YefM
• Location: 1938587..1939089
• Replicon: chromosome
• Accession: NZ_AP026788
• Organism: Escherichia coli strain IPCEC42

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: E2QNP2
• Locus tag: OPA56_RS09190
• Protein ID: WP_000767819.1
• Coordinates: 1938835..1939089 (+)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: E2QNP3
• Locus tag: OPA56_RS09185
• Protein ID: WP_001259253.1
• Coordinates: 1938587..1938838 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
OPA56_RS09160 (1933765)	1933765..1934832	-	1068	WP_000080057.1	bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB	-
OPA56_RS09165 (1934832)	1934832..1935902	-	1071	WP_000108967.1	histidinol-phosphate transaminase	-
OPA56_RS09170 (1935899)	1935899..1937203	-	1305	WP_001296211.1	histidinol dehydrogenase	-
OPA56_RS09175 (1937209)	1937209..1938108	-	900	WP_000131782.1	ATP phosphoribosyltransferase	-
OPA56_RS09180 (1938254)	1938254..1938304	-	51	WP_001364200.1	his operon leader peptide	-
OPA56_RS09185 (1938587)	1938587..1938838	+	252	WP_001259253.1	YoeB-YefM toxin-antitoxin system antitoxin YefM	Antitoxin
OPA56_RS09190 (1938835)	1938835..1939089	+	255	WP_000767819.1	type II toxin-antitoxin system mRNA interferase toxin YoeB	Toxin
OPA56_RS09195 (1939172)	1939172..1939996	+	825	WP_000754737.1	SDR family oxidoreductase	-
OPA56_RS09200 (1940042)	1940042..1940971	+	930	WP_000803366.1	LysR substrate-binding domain-containing protein	-
OPA56_RS09205 (1941186)	1941186..1941248	+	63	WP_010723108.1	membrane protein YoeI	-
OPA56_RS09210 (1941238)	1941238..1942596	+	1359	WP_000019194.1	putrescine/proton symporter PlaP	-
OPA56_RS09215 (1942813)	1942813..1943271	+	459	WP_001531805.1	IS200/IS605-like element IS200C family transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	1942813..1943271	458

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (2-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-72)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 10110.53 Da
• Isoelectric Point: 7.2749

>T42691 WP_000767819.1 NZ_AP026788:1938835-1939089 [Escherichia coli]
VKLIWSEESWDDYLYWQEADKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHLLVYAVTDDSLLIAAC
RYHY

Nucleotide

• Length: 255 bp

>T42691 NZ_AP026788:1938835-1939089 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAGCAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACACCATTTGAAGGTAAGGGGAAACCAGAACCCCTGAAACATAACTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCTTCTGGTATACGCGGTTACTGATGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9365.62 Da
• Isoelectric Point: 4.6127

>AT42691 WP_001259253.1 NZ_AP026788:1938587-1938838 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSDKGTEKD
IIE

Nucleotide

• Length: 252 bp

>AT42691 NZ_AP026788:1938587-1938838 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTCATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGACAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Structures

Toxin

• AlphaFold DB: E2QNP2

Antitoxin

• AlphaFold DB: E2QNP3