Detailed information of TA system TA042639

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/RelE-MqsA
• Location: 1360947..1361580
• Replicon: chromosome
• Accession: NZ_AP026763
• Organism: Vibrio sp. STUT-A11

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: OO774_RS06510
• Protein ID: WP_264905622.1
• Coordinates: 1360947..1361279 (+)
• Length: 111 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: OO774_RS06515
• Protein ID: WP_089202944.1
• Coordinates: 1361266..1361580 (+)
• Length: 105 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
OO774_RS06480 (VspSTUT11_11890)	1356138..1356344	+	207	WP_264905653.1	membrane protein insertion efficiency factor YidD	-
OO774_RS06485 (VspSTUT11_11900)	1356344..1356733	+	390	WP_264905654.1	hypothetical protein	-
OO774_RS06490 (VspSTUT11_11910)	1356988..1357230	+	243	WP_264905656.1	hypothetical protein	-
OO774_RS06495 (VspSTUT11_11920)	1358519..1358881	+	363	WP_264905658.1	DUF1778 domain-containing protein	-
OO774_RS06500 (VspSTUT11_11930)	1358878..1359411	+	534	WP_264905660.1	GNAT family N-acetyltransferase	-
OO774_RS06505 (VspSTUT11_11940)	1359523..1360722	-	1200	WP_263837029.1	IS4 family transposase	-
OO774_RS06510 (VspSTUT11_11950)	1360947..1361279	+	333	WP_264905622.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
OO774_RS06515 (VspSTUT11_11960)	1361266..1361580	+	315	WP_089202944.1	DNA-binding transcriptional regulator	Antitoxin
OO774_RS06520	1362201..1362292	+	92	Protein_1204	DUF3265 domain-containing protein	-
OO774_RS06525 (VspSTUT11_11970)	1362402..1363193	+	792	WP_264905662.1	PhzF family phenazine biosynthesis protein	-
OO774_RS06530	1363193..1363318	+	126	WP_264905664.1	DUF3265 domain-containing protein	-
OO774_RS06535 (VspSTUT11_11980)	1363345..1363779	+	435	WP_264905666.1	GNAT family N-acetyltransferase	-
OO774_RS06540 (VspSTUT11_11990)	1363952..1364368	+	417	WP_264905668.1	hypothetical protein	-
OO774_RS06545 (VspSTUT11_12000)	1364347..1364751	+	405	WP_264905670.1	hypothetical protein	-
OO774_RS06550 (VspSTUT11_12010)	1364886..1366085	-	1200	WP_263837029.1	IS4 family transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-2 (4-104)

Antitoxin

• Cro/C1-type helix-turn-helix domain (43-92)

Sequences

Toxin

Protein

• Length: 111 a.a.
• Molecular weight: 12950.81 Da
• Isoelectric Point: 10.0960

>T42639 WP_264905622.1 NZ_AP026763:1360947-1361279 [Vibrio sp. STUT-A11]
MKSVFVESTIFEKYRNEYLSDEEFRLFQAELMSNPKQGDVIQGTGGLRKIRVASKGKGKRGGSRVIYYFLDEKRRFYLLT
IYGKNEMSDLTADQKKQLKTFMEAWRNEQS

Nucleotide

• Length: 333 bp

>T42639 NZ_AP026763:1360947-1361279 [Vibrio sp. STUT-A11]
ATGAAAAGTGTATTTGTTGAATCAACCATATTTGAAAAGTACCGAAATGAATACCTCAGTGACGAGGAGTTTCGACTGTT
CCAAGCTGAACTTATGTCGAACCCGAAGCAAGGTGACGTAATTCAAGGTACAGGTGGTTTGCGGAAGATTCGAGTTGCAA
GCAAAGGTAAGGGCAAGCGTGGTGGTTCACGTGTTATCTATTACTTCCTCGATGAAAAGCGTCGTTTCTATTTGCTGACC
ATTTACGGCAAAAATGAAATGTCAGACTTAACCGCAGATCAAAAGAAACAGTTAAAGACTTTTATGGAGGCGTGGCGCAA
TGAGCAATCGTGA

Antitoxin

Protein

• Length: 105 a.a.
• Molecular weight: 11704.17 Da
• Isoelectric Point: 6.3290

>AT42639 WP_089202944.1 NZ_AP026763:1361266-1361580 [Vibrio sp. STUT-A11]
MSNRDLFAELSSALVEAKEHSEGKVTLKTHQINDISELNISPDEIVSIREQFNMSRGVFARLLHTSSRTLENWEQGRSAP
NGQAVTLLKLVQRHPETLSHIAEL

Nucleotide

• Length: 315 bp

>AT42639 NZ_AP026763:1361266-1361580 [Vibrio sp. STUT-A11]
ATGAGCAATCGTGACCTATTTGCAGAACTAAGTTCAGCACTTGTTGAAGCTAAGGAGCATTCAGAGGGTAAAGTAACTCT
GAAAACGCACCAAATTAATGACATCAGCGAGTTAAACATCTCGCCTGATGAAATTGTTAGTATTCGTGAGCAATTTAATA
TGTCTCGTGGTGTATTTGCACGTTTGCTACATACATCATCACGTACATTAGAAAACTGGGAGCAGGGGCGTAGCGCACCA
AATGGGCAAGCTGTTACTCTTCTAAAATTGGTACAGCGTCACCCAGAAACTCTGTCGCACATCGCAGAGCTATAA