Detailed information of TA system TA042636

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/RelE-MqsA
• Location: 1336330..1336963
• Replicon: chromosome
• Accession: NZ_AP026763
• Organism: Vibrio sp. STUT-A11

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: OO774_RS06330
• Protein ID: WP_264905622.1
• Coordinates: 1336330..1336662 (+)
• Length: 111 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: OO774_RS06335
• Protein ID: WP_089202944.1
• Coordinates: 1336649..1336963 (+)
• Length: 105 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
OO774_RS06280 (VspSTUT11_11600)	1331879..1332571	+	693	WP_264905608.1	hypothetical protein	-
OO774_RS06285	1332593..1332685	+	93	WP_264905610.1	DUF3265 domain-containing protein	-
OO774_RS06290 (VspSTUT11_11610)	1332713..1333300	+	588	WP_162048022.1	hypothetical protein	-
OO774_RS06295	1333321..1333413	+	93	WP_264905612.1	DUF3265 domain-containing protein	-
OO774_RS06300	1333872..1333961	+	90	WP_264906076.1	DUF3265 domain-containing protein	-
OO774_RS06305 (VspSTUT11_11620)	1334007..1334915	+	909	WP_264905614.1	hypothetical protein	-
OO774_RS06310 (VspSTUT11_11630)	1335103..1335369	+	267	WP_264905616.1	BrnT family toxin	-
OO774_RS06315 (VspSTUT11_11640)	1335356..1335598	+	243	WP_264905618.1	BrnA antitoxin family protein	-
OO774_RS06320 (VspSTUT11_11650)	1335743..1336120	+	378	WP_264905620.1	hypothetical protein	-
OO774_RS06325	1336114..1336182	+	69	Protein_1165	DUF3265 domain-containing protein	-
OO774_RS06330 (VspSTUT11_11660)	1336330..1336662	+	333	WP_264905622.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
OO774_RS06335 (VspSTUT11_11670)	1336649..1336963	+	315	WP_089202944.1	DNA-binding transcriptional regulator	Antitoxin
OO774_RS06340 (VspSTUT11_11680)	1338205..1338630	+	426	WP_264906077.1	GNAT family N-acetyltransferase	-
OO774_RS06345 (VspSTUT11_11690)	1339248..1340027	+	780	WP_264905625.1	hypothetical protein	-
OO774_RS06350 (VspSTUT11_11700)	1340155..1341354	-	1200	WP_263837029.1	IS4 family transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integron	-	-	1330678..1358881	28203

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-2 (4-104)

Antitoxin

• Cro/C1-type helix-turn-helix domain (43-92)

Sequences

Toxin

Protein

• Length: 111 a.a.
• Molecular weight: 12950.81 Da
• Isoelectric Point: 10.0960

>T42636 WP_264905622.1 NZ_AP026763:1336330-1336662 [Vibrio sp. STUT-A11]
MKSVFVESTIFEKYRNEYLSDEEFRLFQAELMSNPKQGDVIQGTGGLRKIRVASKGKGKRGGSRVIYYFLDEKRRFYLLT
IYGKNEMSDLTADQKKQLKTFMEAWRNEQS

Nucleotide

• Length: 333 bp

>T42636 NZ_AP026763:1336330-1336662 [Vibrio sp. STUT-A11]
ATGAAAAGTGTATTTGTTGAATCAACCATATTTGAAAAGTACCGAAATGAATACCTCAGTGACGAGGAGTTTCGACTGTT
CCAAGCTGAACTTATGTCGAACCCGAAGCAAGGTGACGTAATTCAAGGTACAGGTGGTTTGCGGAAGATTCGAGTTGCAA
GCAAAGGTAAGGGCAAGCGTGGTGGTTCACGTGTTATCTATTACTTCCTCGATGAAAAGCGTCGTTTCTATTTGCTGACC
ATTTACGGCAAAAATGAAATGTCAGACTTAACCGCAGATCAAAAGAAACAGTTAAAGACTTTTATGGAGGCGTGGCGCAA
TGAGCAATCGTGA

Antitoxin

Protein

• Length: 105 a.a.
• Molecular weight: 11704.17 Da
• Isoelectric Point: 6.3290

>AT42636 WP_089202944.1 NZ_AP026763:1336649-1336963 [Vibrio sp. STUT-A11]
MSNRDLFAELSSALVEAKEHSEGKVTLKTHQINDISELNISPDEIVSIREQFNMSRGVFARLLHTSSRTLENWEQGRSAP
NGQAVTLLKLVQRHPETLSHIAEL

Nucleotide

• Length: 315 bp

>AT42636 NZ_AP026763:1336649-1336963 [Vibrio sp. STUT-A11]
ATGAGCAATCGTGACCTATTTGCAGAACTAAGTTCAGCACTTGTTGAAGCTAAGGAGCATTCAGAGGGTAAAGTAACTCT
GAAAACGCACCAAATTAATGACATCAGCGAGTTAAACATCTCGCCTGATGAAATTGTTAGTATTCGTGAGCAATTTAATA
TGTCTCGTGGTGTATTTGCACGTTTGCTACATACATCATCACGTACATTAGAAAACTGGGAGCAGGGGCGTAGCGCACCA
AATGGGCAAGCTGTTACTCTTCTAAAATTGGTACAGCGTCACCCAGAAACTCTGTCGCACATCGCAGAGCTATAA