Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-ratA/-
Location 3056880..3057217 Replicon chromosome
Accession NZ_AP026721
Organism Enterococcus faecalis strain SVR2330

Toxin (Protein)


Gene name txpA Uniprot ID A0A1J6YG70
Locus tag PO855_RS15085 Protein ID WP_002396786.1
Coordinates 3056880..3057023 (+) Length 48 a.a.

Antitoxin (RNA)


Gene name ratA
Locus tag -
Coordinates 3056955..3057217 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PO855_RS15070 3052536..3053168 - 633 WP_002358972.1 RloB family protein -
PO855_RS15075 3053177..3054472 - 1296 WP_010815865.1 ATP-binding protein -
PO855_RS15080 3054934..3056550 + 1617 WP_172494128.1 phosphatase PAP2/LCP family protein -
PO855_RS15085 3056880..3057023 + 144 WP_002396786.1 putative holin-like toxin Toxin
- 3056955..3057217 - 263 - - Antitoxin
PO855_RS15090 3057218..3061909 - 4692 WP_010815866.1 WxL domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(14-47)


Sequences

Toxin        


Download         Length: 48 a.a.        Molecular weight: 5203.19 Da        Isoelectric Point: 8.6626

>T42621 WP_002396786.1 NZ_AP026721:3056880-3057023 [Enterococcus faecalis]
MNVSTKIYERRGLLSIAEALALMISFGSFIATLIFGILEAVKEDNKK

Download         Length: 144 bp

>T42621 NZ_AP026721:3056880-3057023 [Enterococcus faecalis]
ATGAATGTAAGTACTAAAATCTATGAAAGGAGAGGCCTTTTGTCTATCGCAGAAGCTTTAGCTCTGATGATTAGTTTCGG
TTCTTTTATCGCAACGTTAATCTTCGGAATCCTAGAGGCTGTTAAAGAAGACAATAAAAAATAA

Antitoxin


Download         Length: 263 bp

>AT42621 NZ_AP026721:c3057217-3056955 [Enterococcus faecalis]
AAATAAAAATGCCCGAGCCTCTTATTTTTCTAAGGCTCGGGCATTTTTATTGATGGTCTTTTGAGGGTCGTTGTGCTATA
ATGGTAATGAAAAGAGAGGTATGCGCCAACATACCTCTCTAGTGTAGAGCCGTTTCAGACGGTAGCGATTTTTAGTGATT
TATAAAAAATAACCGTGCTCGCTAAAGTTGACGGTTATTTTTTATTGTCTTCTTTAACAGCCTCTAGGATTCCGAAGATT
AACGTTGCGATAAAAGAACCGAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1J6YG70

Antitoxin

Download structure file

References