Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-ratA/-
Location 616149..616381 Replicon chromosome
Accession NZ_AP026721
Organism Enterococcus faecalis strain SVR2330

Toxin (Protein)


Gene name txpA Uniprot ID C7CXQ5
Locus tag PO855_RS03115 Protein ID WP_002355568.1
Coordinates 616149..616265 (+) Length 39 a.a.

Antitoxin (RNA)


Gene name ratA
Locus tag -
Coordinates 616176..616381 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PO855_RS03105 611587..613845 + 2259 WP_002363179.1 DNA helicase PcrA -
PO855_RS03110 613971..616001 + 2031 WP_002358699.1 NAD-dependent DNA ligase LigA -
PO855_RS03115 616149..616265 + 117 WP_002355568.1 putative holin-like toxin Toxin
- 616176..616381 - 206 - - Antitoxin
PO855_RS03120 616583..616888 + 306 WP_002355569.1 Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatC -
PO855_RS03125 616888..618357 + 1470 WP_002358701.1 Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatA -
PO855_RS03130 618357..619787 + 1431 WP_002358703.1 Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatB -
PO855_RS03135 619806..620894 + 1089 WP_240068507.1 diacylglycerol kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(3-35)


Sequences

Toxin        


Download         Length: 39 a.a.        Molecular weight: 4065.93 Da        Isoelectric Point: 5.9482

>T42612 WP_002355568.1 NZ_AP026721:616149-616265 [Enterococcus faecalis]
MFLSVEAALGLMIGFATLVVTIIFGILALVLDNKNNRS

Download         Length: 117 bp

>T42612 NZ_AP026721:616149-616265 [Enterococcus faecalis]
ATGTTTTTGTCCGTTGAAGCAGCGCTAGGACTGATGATTGGTTTTGCAACACTTGTTGTGACCATTATCTTCGGTATCTT
AGCGCTTGTCTTAGACAACAAAAATAACCGTTCATAA

Antitoxin


Download         Length: 206 bp

>AT42612 NZ_AP026721:c616381-616176 [Enterococcus faecalis]
AAAAGAGAGATATGCAGGAACATACCTCTCTAATAGCCACTACTAGTTATAAGAACTAGCGGCTTACTGAGTTATTGGTT
TTATTTCAAACGCTTAACCGTTCAGCTCCTCAAAGCTTATGAACGGTTATTTTTGTTGTCTAAGACAAGCGCTAAGATAC
CGAAGATAATGGTCACAACAAGTGTTGCAAAACCAATCATCAGTCC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1B4XLM6

Antitoxin

Download structure file

References