Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 506872..507310 Replicon chromosome
Accession NZ_AP026710
Organism Cutibacterium granulosum strain TP-CG7 isolate Human

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag TPCG7_RS02085 Protein ID WP_249361191.1
Coordinates 506872..506967 (+) Length 32 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag TPCG7_RS02090 Protein ID WP_286320899.1
Coordinates 506957..507310 (+) Length 118 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
TPCG7_RS02075 (TPCG7_04040) 502733..504022 + 1290 WP_286320890.1 M18 family aminopeptidase -
TPCG7_RS02080 (TPCG7_04050) 504078..505151 + 1074 WP_286320893.1 redox-regulated ATPase YchF -
TPCG7_RS02085 506872..506967 + 96 WP_249361191.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
TPCG7_RS02090 (TPCG7_04060) 506957..507310 + 354 WP_286320899.1 HigA family addiction module antitoxin Antitoxin
TPCG7_RS02095 (TPCG7_04070) 507416..507895 + 480 WP_286320901.1 GNAT family N-acetyltransferase -
TPCG7_RS02100 508715..508912 + 198 WP_286321901.1 CopG family transcriptional regulator -
TPCG7_RS02105 (TPCG7_04090) 508909..509289 + 381 WP_286320903.1 type II toxin-antitoxin system death-on-curing family toxin -
TPCG7_RS02110 (TPCG7_04100) 509481..509702 + 222 WP_286320905.1 nucleotidyltransferase domain-containing protein -
TPCG7_RS02115 (TPCG7_04110) 509991..510512 + 522 WP_286320908.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(3-31)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(27-111)


Sequences

Toxin        


Download         Length: 32 a.a.        Molecular weight: 3499.95 Da        Isoelectric Point: 7.0060

>T42607 WP_249361191.1 NZ_AP026710:506872-506967 [Cutibacterium granulosum]
MLEDLRVPPGNRLEALKGDRAGQHSIRINDQ

Download         Length: 96 bp

>T42607 NZ_AP026710:506872-506967 [Cutibacterium granulosum]
ATGCTCGAAGACCTCCGCGTCCCACCCGGTAACCGACTCGAGGCGCTCAAGGGCGACCGAGCTGGTCAGCACAGCATCAG
AATCAATGACCAGTGA

Antitoxin


Download         Length: 118 a.a.        Molecular weight: 13003.55 Da        Isoelectric Point: 5.1407

>AT42607 WP_286320899.1 NZ_AP026710:506957-507310 [Cutibacterium granulosum]
MTSDGSVSDGQTPDQRRWRSLTTTDEIEPIHPGEVLMEDFIEGFGITQHKLAVSIGVPPRRINEIVHGKRGISADTALRL
AKYFGTSATFWTNLQSHYELDRAEDAAAEQIMPLHVA

Download         Length: 354 bp

>AT42607 NZ_AP026710:506957-507310 [Cutibacterium granulosum]
ATGACCAGTGACGGATCTGTTTCAGATGGACAGACGCCGGACCAGAGGAGGTGGAGATCGTTGACTACTACTGACGAGAT
CGAGCCGATCCATCCGGGAGAAGTTCTCATGGAGGACTTCATCGAGGGCTTCGGGATCACACAGCACAAGCTCGCTGTGT
CGATAGGTGTGCCGCCGCGGCGGATCAACGAGATCGTGCACGGCAAGCGAGGGATCTCAGCGGACACCGCATTGCGACTC
GCGAAGTACTTCGGAACCTCGGCGACATTCTGGACCAACCTGCAGAGCCACTACGAGCTCGACCGTGCGGAAGACGCGGC
AGCTGAGCAGATCATGCCGCTACACGTGGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References