Detailed information of TA system TA042607

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-VapI
• Location: 506872..507310
• Replicon: chromosome
• Accession: NZ_AP026710
• Organism: Cutibacterium granulosum strain TP-CG7 isolate Human

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: TPCG7_RS02085
• Protein ID: WP_249361191.1
• Coordinates: 506872..506967 (+)
• Length: 32 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: TPCG7_RS02090
• Protein ID: WP_286320899.1
• Coordinates: 506957..507310 (+)
• Length: 118 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
TPCG7_RS02075 (TPCG7_04040)	502733..504022	+	1290	WP_286320890.1	M18 family aminopeptidase	-
TPCG7_RS02080 (TPCG7_04050)	504078..505151	+	1074	WP_286320893.1	redox-regulated ATPase YchF	-
TPCG7_RS02085	506872..506967	+	96	WP_249361191.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
TPCG7_RS02090 (TPCG7_04060)	506957..507310	+	354	WP_286320899.1	HigA family addiction module antitoxin	Antitoxin
TPCG7_RS02095 (TPCG7_04070)	507416..507895	+	480	WP_286320901.1	GNAT family N-acetyltransferase	-
TPCG7_RS02100	508715..508912	+	198	WP_286321901.1	CopG family transcriptional regulator	-
TPCG7_RS02105 (TPCG7_04090)	508909..509289	+	381	WP_286320903.1	type II toxin-antitoxin system death-on-curing family toxin	-
TPCG7_RS02110 (TPCG7_04100)	509481..509702	+	222	WP_286320905.1	nucleotidyltransferase domain-containing protein	-
TPCG7_RS02115 (TPCG7_04110)	509991..510512	+	522	WP_286320908.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-1 (3-31)

Antitoxin

• Toxin-antitoxin system, antidote protein, HigA (27-111)

Sequences

Toxin

Protein

• Length: 32 a.a.
• Molecular weight: 3499.95 Da
• Isoelectric Point: 7.0060

>T42607 WP_249361191.1 NZ_AP026710:506872-506967 [Cutibacterium granulosum]
MLEDLRVPPGNRLEALKGDRAGQHSIRINDQ

Nucleotide

• Length: 96 bp

>T42607 NZ_AP026710:506872-506967 [Cutibacterium granulosum]
ATGCTCGAAGACCTCCGCGTCCCACCCGGTAACCGACTCGAGGCGCTCAAGGGCGACCGAGCTGGTCAGCACAGCATCAG
AATCAATGACCAGTGA

Antitoxin

Protein

• Length: 118 a.a.
• Molecular weight: 13003.55 Da
• Isoelectric Point: 5.1407

>AT42607 WP_286320899.1 NZ_AP026710:506957-507310 [Cutibacterium granulosum]
MTSDGSVSDGQTPDQRRWRSLTTTDEIEPIHPGEVLMEDFIEGFGITQHKLAVSIGVPPRRINEIVHGKRGISADTALRL
AKYFGTSATFWTNLQSHYELDRAEDAAAEQIMPLHVA

Nucleotide

• Length: 354 bp

>AT42607 NZ_AP026710:506957-507310 [Cutibacterium granulosum]
ATGACCAGTGACGGATCTGTTTCAGATGGACAGACGCCGGACCAGAGGAGGTGGAGATCGTTGACTACTACTGACGAGAT
CGAGCCGATCCATCCGGGAGAAGTTCTCATGGAGGACTTCATCGAGGGCTTCGGGATCACACAGCACAAGCTCGCTGTGT
CGATAGGTGTGCCGCCGCGGCGGATCAACGAGATCGTGCACGGCAAGCGAGGGATCTCAGCGGACACCGCATTGCGACTC
GCGAAGTACTTCGGAACCTCGGCGACATTCTGGACCAACCTGCAGAGCCACTACGAGCTCGACCGTGCGGAAGACGCGGC
AGCTGAGCAGATCATGCCGCTACACGTGGCGTGA