Detailed information of TA system TA042606

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/YoeB-YefM
• Location: 260921..261433
• Replicon: chromosome
• Accession: NZ_AP026710
• Organism: Cutibacterium granulosum strain TP-CG7 isolate Human

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: TPCG7_RS01050
• Protein ID: WP_286320562.1
• Coordinates: 260921..261175 (-)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: TPCG7_RS01055
• Protein ID: WP_286320564.1
• Coordinates: 261179..261433 (-)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
TPCG7_RS01035	257733..258353	-	621	Protein_201	choice-of-anchor M domain-containing protein	-
TPCG7_RS01040 (TPCG7_02010)	258558..259712	+	1155	WP_023034886.1	hypothetical protein	-
TPCG7_RS01045 (TPCG7_02020)	260052..260858	+	807	WP_286321828.1	HesA/MoeB/ThiF family protein	-
TPCG7_RS01050	260921..261175	-	255	WP_286320562.1	Txe/YoeB family addiction module toxin	Toxin
TPCG7_RS01055 (TPCG7_02030)	261179..261433	-	255	WP_286320564.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
TPCG7_RS01060 (TPCG7_02040)	261824..263479	+	1656	WP_286320566.1	histidine-type phosphatase	-
TPCG7_RS01065 (TPCG7_02060)	263646..265046	+	1401	WP_286320567.1	CAP domain-containing protein	-
TPCG7_RS01075 (TPCG7_02070)	265483..266148	-	666	WP_023034891.1	SDR family oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (1-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-73)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 10226.47 Da
• Isoelectric Point: 9.4032

>T42606 WP_286320562.1 NZ_AP026710:c261175-260921 [Cutibacterium granulosum]
MRIIWDQSAWNEYLWWQSHDRRVLNRINQLIKDVSHNGNDGIGKPEALRYSLSGYWSRRINDEHRLVYKISGNDIWIASC
RYQY

Nucleotide

• Length: 255 bp

>T42606 NZ_AP026710:c261175-260921 [Cutibacterium granulosum]
ATGCGTATTATCTGGGACCAATCCGCATGGAATGAATATCTCTGGTGGCAGAGCCATGATCGCAGGGTCCTCAACCGAAT
CAACCAACTCATCAAGGATGTGTCACACAATGGCAACGATGGGATAGGAAAACCGGAAGCTTTGAGATATTCGCTATCAG
GATATTGGTCGCGTAGAATCAATGATGAACATCGTTTGGTGTACAAAATTTCCGGTAACGACATATGGATAGCAAGCTGC
CGATATCAATATTGA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9541.60 Da
• Isoelectric Point: 4.6602

>AT42606 WP_286320564.1 NZ_AP026710:c261433-261179 [Cutibacterium granulosum]
MKTLSYTQSRAQYAKMLDDVVADREETIVTRSGHDPVVIVSLEDYQSLRETAYLLRSPANARHLLDSIERLEDGHGTEHG
LIEE

Nucleotide

• Length: 255 bp

>AT42606 NZ_AP026710:c261433-261179 [Cutibacterium granulosum]
ATGAAAACACTCAGCTACACCCAGTCCCGGGCTCAGTACGCCAAGATGCTTGACGACGTCGTGGCAGACCGCGAGGAGAC
CATCGTCACACGATCTGGCCACGATCCCGTAGTAATTGTCTCCTTGGAGGATTACCAGTCACTGCGTGAAACTGCGTACC
TACTACGGTCACCTGCAAATGCCCGCCATCTTCTGGACTCCATCGAGAGACTCGAGGATGGACACGGCACAGAGCACGGC
CTCATCGAAGAATGA