Detailed information of TA system TA042597

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HTH(antitoxin)
• Location: 4483936..4484538
• Replicon: chromosome
• Accession: NZ_AP026680
• Organism: Salmonella enterica subsp. enterica serovar Oranienburg strain 11548

Toxin (Protein)

• Gene name: higB
• Uniprot ID: V7IUJ1
• Locus tag: QMM99_RS21740
• Protein ID: WP_001159632.1
• Coordinates: 4484227..4484538 (-)
• Length: 104 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: QMM99_RS21735
• Protein ID: WP_000362050.1
• Coordinates: 4483936..4484226 (-)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
QMM99_RS21720 (4481429)	4481429..4482331	+	903	WP_000331360.1	formate dehydrogenase subunit beta	-
QMM99_RS21725 (4482328)	4482328..4482963	+	636	WP_000829025.1	formate dehydrogenase cytochrome b556 subunit	-
QMM99_RS21730 (4482960)	4482960..4483889	+	930	WP_000027730.1	formate dehydrogenase accessory protein FdhE	-
QMM99_RS21735 (4483936)	4483936..4484226	-	291	WP_000362050.1	DNA-binding transcriptional regulator	Antitoxin
QMM99_RS21740 (4484227)	4484227..4484538	-	312	WP_001159632.1	cytotoxic translational repressor of toxin-antitoxin stability system	Toxin
QMM99_RS21745 (4484756)	4484756..4485685	+	930	Protein_4243	alpha/beta hydrolase	-
QMM99_RS21750 (4485771)	4485771..4486082	+	312	WP_000558166.1	type II toxin-antitoxin system HigB family toxin	-
QMM99_RS21755 (4486079)	4486079..4486525	+	447	WP_001259011.1	type II toxin-antitoxin system HigA family antitoxin	-
QMM99_RS21760 (4486540)	4486540..4487481	-	942	WP_001518251.1	fatty acid biosynthesis protein FabY	-
QMM99_RS21765 (4487526)	4487526..4487963	-	438	WP_000560969.1	D-aminoacyl-tRNA deacylase	-
QMM99_RS21770 (4487960)	4487960..4488832	-	873	WP_000921423.1	virulence factor BrkB family protein	-
QMM99_RS21775 (4488826)	4488826..4489425	-	600	WP_000965698.1	glucose-1-phosphatase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	4476036..4486525	10489

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Cro/C1-type helix-turn-helix domain (36-85)

Sequences

Toxin

Protein

• Length: 104 a.a.
• Molecular weight: 12342.27 Da
• Isoelectric Point: 9.4460

>T42597 WP_001159632.1 NZ_AP026680:c4484538-4484227 [Salmonella enterica subsp. enterica serovar Oranienburg]
MQFIETELFTEDVKKLLDDDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGSRGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Nucleotide

• Length: 312 bp

>T42597 NZ_AP026680:c4484538-4484227 [Salmonella enterica subsp. enterica serovar Oranienburg]
ATGCAATTTATAGAAACGGAACTCTTTACTGAAGATGTTAAAAAACTGCTCGATGATGATGAATACCATAAGCTTCAGGT
TTTTATGGCTCAGCATCCAGATTGTGGTGATGTCATTCAGGAAACGGGCGGCCTGAGAAAAATGCGCTGGGGATCGCGAG
GCAAAGGAAAGCGTAGTGGCGTGCGAATTATCTATTTTCACCGTAGTCAACGGTATGAGATTCGCTTGCTTCTGATTTAT
CAAAAAGGCATTAAAGATGATCTCACGCCGCAGGAAAAAGCGGTACTTCGTATGCTGAATGAGAGGTGGTAG

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10971.59 Da
• Isoelectric Point: 10.6525

>AT42597 WP_000362050.1 NZ_AP026680:c4484226-4483936 [Salmonella enterica subsp. enterica serovar Oranienburg]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Nucleotide

• Length: 291 bp

>AT42597 NZ_AP026680:c4484226-4483936 [Salmonella enterica subsp. enterica serovar Oranienburg]
ATGGATAAAGTGTTATTTGAGCGATTAACTCAAAGTATGTCTCAAATGAATGAAATCATTGAAGGGACCCGTGAGCCTTC
TCGTACCTTTCATATTGATGCAATGAAGATTAAAGAAATACGGCAGGCATCTGGGTTGTCGCAATCTAAGTTTGCAGAAC
TGATTTCGGTCAACGTGGATACGCTGCGCAACTGGGAGCAAGGAAGACGTTCACCGACAGGGCCAGCCAAAGCGTTACTT
CGCGCCATTGCCAACGACCCGAGAAACGTTATACAAGCATTGCGTTATTGA

Structures

Toxin

• AlphaFold DB: A0A4U7VQ31