Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | yefM-yoeB (relBE)/Txe-RelB |
Location | 64262..64797 | Replicon | plasmid pAA94_1 |
Accession | NZ_AP026613 | ||
Organism | Enterococcus faecium strain AA94 |
Toxin (Protein)
Gene name | yoeB | Uniprot ID | R2PQC0 |
Locus tag | OQH77_RS14555 | Protein ID | WP_002314366.1 |
Coordinates | 64262..64534 (-) | Length | 91 a.a. |
Antitoxin (Protein)
Gene name | yefM | Uniprot ID | Q3Y220 |
Locus tag | OQH77_RS14560 | Protein ID | WP_002297422.1 |
Coordinates | 64534..64797 (-) | Length | 88 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
OQH77_RS14515 (EfmAA94_28550) | 59512..59991 | - | 480 | Protein_62 | type IV secretory system conjugative DNA transfer family protein | - |
OQH77_RS14520 (EfmAA94_28560) | 59988..60464 | - | 477 | WP_002317294.1 | PcfB family protein | - |
OQH77_RS14525 (EfmAA94_28570) | 60539..60751 | - | 213 | WP_002317295.1 | DUF5348 domain-containing protein | - |
OQH77_RS14530 (EfmAA94_28580) | 60773..61973 | - | 1201 | Protein_65 | helix-turn-helix domain-containing protein | - |
OQH77_RS14535 (EfmAA94_28600) | 62250..62441 | - | 192 | Protein_66 | hypothetical protein | - |
OQH77_RS14540 (EfmAA94_28610) | 62442..63299 | - | 858 | WP_002292680.1 | ParA family protein | - |
OQH77_RS14545 | 63713..63866 | - | 154 | Protein_68 | type II toxin-antitoxin system RelE/ParE family toxin | - |
OQH77_RS14550 (EfmAA94_28620) | 63856..64185 | - | 330 | WP_002292678.1 | AbrB family transcriptional regulator | - |
OQH77_RS14555 (EfmAA94_28630) | 64262..64534 | - | 273 | WP_002314366.1 | Txe/YoeB family addiction module toxin | Toxin |
OQH77_RS14560 (EfmAA94_28640) | 64534..64797 | - | 264 | WP_002297422.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
OQH77_RS14565 | 65031..65938 | + | 908 | Protein_72 | IS982 family transposase | - |
OQH77_RS14570 (EfmAA94_28680) | 65941..67116 | - | 1176 | WP_002336205.1 | MFS transporter | - |
OQH77_RS14575 (EfmAA94_28690) | 67119..69368 | - | 2250 | WP_002314387.1 | alpha-galactosidase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Mobilizable plasmid | VanHBX / ant(6)-Ia / erm(B) | - | 1..321364 | 321364 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 91 a.a. Molecular weight: 10780.24 Da Isoelectric Point: 9.9724
>T42561 WP_002314366.1 NZ_AP026613:c64534-64262 [Enterococcus faecium]
MNNYSVMIKNSAKADLKKIKQSNLKPQFEKVIQTLKEDPYLPTQSFEKLKPTHEGRYSRRLNRQHRVVYKVDEDEHVVEI
YSARTHYESQ
MNNYSVMIKNSAKADLKKIKQSNLKPQFEKVIQTLKEDPYLPTQSFEKLKPTHEGRYSRRLNRQHRVVYKVDEDEHVVEI
YSARTHYESQ
Download Length: 273 bp
>T42561 NZ_AP026613:c64534-64262 [Enterococcus faecium]
ATGAATAACTATTCTGTGATGATTAAAAACTCGGCTAAAGCTGATTTAAAGAAAATCAAACAGTCTAATTTGAAACCTCA
ATTTGAGAAGGTTATTCAGACTTTAAAGGAAGATCCCTATCTCCCTACCCAATCATTTGAGAAGTTAAAACCTACACATG
AAGGTAGGTATTCTAGAAGATTGAATAGACAACACCGGGTTGTTTATAAGGTAGATGAAGATGAACACGTGGTTGAAATT
TATTCAGCAAGGACGCATTACGAGTCACAGTAA
ATGAATAACTATTCTGTGATGATTAAAAACTCGGCTAAAGCTGATTTAAAGAAAATCAAACAGTCTAATTTGAAACCTCA
ATTTGAGAAGGTTATTCAGACTTTAAAGGAAGATCCCTATCTCCCTACCCAATCATTTGAGAAGTTAAAACCTACACATG
AAGGTAGGTATTCTAGAAGATTGAATAGACAACACCGGGTTGTTTATAAGGTAGATGAAGATGAACACGTGGTTGAAATT
TATTCAGCAAGGACGCATTACGAGTCACAGTAA
Antitoxin
Download Length: 88 a.a. Molecular weight: 9959.22 Da Isoelectric Point: 4.5370
>AT42561 WP_002297422.1 NZ_AP026613:c64797-64534 [Enterococcus faecium]
MAKTVLNPSSARKNFYKLLKDVNENHTEIEIISERSENNAVLIGLDDWKAIKETLLLEQIGTLGVVRKREKDDSGFTNVD
EIDWDNL
MAKTVLNPSSARKNFYKLLKDVNENHTEIEIISERSENNAVLIGLDDWKAIKETLLLEQIGTLGVVRKREKDDSGFTNVD
EIDWDNL
Download Length: 264 bp
>AT42561 NZ_AP026613:c64797-64534 [Enterococcus faecium]
ATGGCAAAAACAGTCTTAAATCCTAGCTCAGCACGGAAAAATTTTTATAAGTTGTTGAAAGATGTAAATGAGAATCATAC
GGAAATTGAAATCATTAGTGAGCGCAGTGAAAATAATGCGGTGCTTATTGGTTTGGATGATTGGAAAGCAATCAAAGAAA
CGCTATTACTTGAGCAAATAGGCACTTTGGGTGTTGTTCGTAAGCGAGAAAAAGATGATAGTGGATTTACTAATGTTGAT
GAAATTGATTGGGATAACTTATAA
ATGGCAAAAACAGTCTTAAATCCTAGCTCAGCACGGAAAAATTTTTATAAGTTGTTGAAAGATGTAAATGAGAATCATAC
GGAAATTGAAATCATTAGTGAGCGCAGTGAAAATAATGCGGTGCTTATTGGTTTGGATGATTGGAAAGCAATCAAAGAAA
CGCTATTACTTGAGCAAATAGGCACTTTGGGTGTTGTTCGTAAGCGAGAAAAAGATGATAGTGGATTTACTAATGTTGAT
GAAATTGATTGGGATAACTTATAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A829F704 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A829F006 |