Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 276803..277448 Replicon plasmid pVV20-8B-2
Accession NZ_AP026554
Organism Vibrio vulnificus strain VV20-8B-2 isolate homogenised shrimp

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag OO986_RS24285 Protein ID WP_258520172.1
Coordinates 276803..277153 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag OO986_RS24290 Protein ID WP_170897565.1
Coordinates 277143..277448 (+) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OO986_RS24265 (VV208B2_46590) 272728..273801 - 1074 WP_258520176.1 tyrosine-type recombinase/integrase -
OO986_RS24270 (VV208B2_46600) 274055..274456 + 402 WP_258520175.1 S24 family peptidase -
OO986_RS24275 274458..275714 + 1257 WP_258520174.1 Y-family DNA polymerase -
OO986_RS24280 (VV208B2_46620) 275903..276529 - 627 WP_258520173.1 recombinase family protein -
OO986_RS24285 (VV208B2_46630) 276803..277153 + 351 WP_258520172.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OO986_RS24290 (VV208B2_46640) 277143..277448 + 306 WP_170897565.1 XRE family transcriptional regulator Antitoxin
OO986_RS24295 (VV208B2_46650) 277835..279067 - 1233 WP_264923151.1 HAMP domain-containing methyl-accepting chemotaxis protein -
OO986_RS24300 (VV208B2_46670) 279191..280314 + 1124 WP_148513603.1 IS3-like element ISVpa4 family transposase -
OO986_RS24305 (VV208B2_46680) 280329..280652 - 324 WP_264923155.1 hypothetical protein -
OO986_RS24310 280894..282428 + 1535 WP_258520148.1 IS3 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid qnrS2 / blaCTX-M-55 - 1..322993 322993


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-105)

Antitoxin

HigA2-like, helix-turn-helix domain

(14-90)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 13475.31 Da        Isoelectric Point: 4.9860

>T42543 WP_258520172.1 NZ_AP026554:276803-277153 [Vibrio vulnificus]
MWNVVTRPLFDEWFLSLDESDQINVRACIQVLLERGPQLSRPYADTVEDSKHSNMKELRVQSNGKPIRAFFAFDPERTGI
ILCGGDKTGDKRFYKKMIPIADAEFDEHLEELKNEK

Download         Length: 351 bp

>T42543 NZ_AP026554:276803-277153 [Vibrio vulnificus]
ATGTGGAATGTAGTAACTAGACCACTTTTTGACGAGTGGTTTCTATCACTAGATGAAAGCGATCAAATTAATGTCCGCGC
ATGCATCCAGGTTCTTCTTGAAAGAGGGCCTCAGCTGAGCAGACCATACGCTGACACTGTGGAAGATTCAAAGCACAGCA
ACATGAAAGAGTTGCGAGTGCAAAGCAATGGGAAACCTATACGGGCTTTCTTTGCTTTTGACCCAGAAAGAACAGGAATT
ATCTTATGTGGCGGTGATAAAACTGGCGATAAGAGATTCTACAAAAAGATGATTCCGATTGCTGATGCAGAATTTGATGA
GCATTTAGAGGAACTTAAAAATGAAAAGTAA

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 10928.77 Da        Isoelectric Point: 8.5752

>AT42543 WP_170897565.1 NZ_AP026554:277143-277448 [Vibrio vulnificus]
MKSNPLSVLDAKMSPEALAAAKEKAADMLLDIRLAELREITHLSQVEIAKAMGISQPSVANLEKSGKDLRLSSLKKYVEA
TGGKLRIDVELPDGKHFGFPV

Download         Length: 306 bp

>AT42543 NZ_AP026554:277143-277448 [Vibrio vulnificus]
ATGAAAAGTAACCCATTAAGCGTACTTGACGCAAAAATGTCACCAGAAGCACTTGCTGCCGCTAAAGAAAAAGCAGCAGA
TATGCTTCTTGACATTCGACTTGCTGAGCTTCGAGAGATCACCCATCTATCTCAAGTAGAAATCGCTAAAGCTATGGGCA
TTAGCCAGCCATCAGTTGCTAATCTAGAGAAATCTGGCAAAGATTTACGTCTTAGCTCTTTAAAGAAATACGTCGAAGCG
ACCGGTGGCAAGCTTCGCATTGATGTAGAACTGCCAGACGGAAAACATTTTGGCTTCCCGGTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References