Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 3841891..3842488 Replicon chromosome
Accession NZ_AP026420
Organism Klebsiella quasipneumoniae subsp. quasipneumoniae strain KAM645

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag OCV84_RS18835 Protein ID WP_049013659.1
Coordinates 3842171..3842488 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag OCV84_RS18830 Protein ID WP_049013658.1
Coordinates 3841891..3842178 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OCV84_RS18800 (3838079) 3838079..3838327 + 249 WP_002893037.1 DUF1158 domain-containing protein -
OCV84_RS18805 (3838345) 3838345..3838686 - 342 WP_004202492.1 RamA family antibiotic efflux transcriptional regulator -
OCV84_RS18810 (3838726) 3838726..3839832 - 1107 WP_261901672.1 MBL fold metallo-hydrolase -
OCV84_RS18815 (3840012) 3840012..3840596 + 585 WP_023288732.1 TetR/AcrR family transcriptional regulator -
OCV84_RS18820 (3840593) 3840593..3840961 + 369 WP_004202487.1 MmcQ/YjbR family DNA-binding protein -
OCV84_RS18825 (3841081) 3841081..3841734 + 654 WP_023288731.1 oxygen-insensitive NAD(P)H nitroreductase -
OCV84_RS18830 (3841891) 3841891..3842178 - 288 WP_049013658.1 helix-turn-helix transcriptional regulator Antitoxin
OCV84_RS18835 (3842171) 3842171..3842488 - 318 WP_049013659.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OCV84_RS18840 (3842673) 3842673..3843716 - 1044 WP_261901673.1 DUF2157 domain-containing protein -
OCV84_RS18845 (3844061) 3844061..3844927 - 867 WP_023288725.1 helix-turn-helix transcriptional regulator -
OCV84_RS18850 (3845036) 3845036..3846463 + 1428 WP_048296961.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-100)

Antitoxin

Cro/C1-type helix-turn-helix domain

(38-88)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12102.38 Da        Isoelectric Point: 11.2767

>T42509 WP_049013659.1 NZ_AP026420:c3842488-3842171 [Klebsiella quasipneumoniae subsp. quasipneumoniae]
MFRMVVHVDVKKELQALPAIVQAKMIRQLDKLRQNPTALREPDSKPLGQGLFEIRALGSVQGRGIYVFQQGKTLFLLRVF
VKKTQKTPSSEIRLALKRLEEMRNE

Download         Length: 318 bp

>T42509 NZ_AP026420:c3842488-3842171 [Klebsiella quasipneumoniae subsp. quasipneumoniae]
ATGTTCAGAATGGTTGTGCACGTGGACGTTAAAAAGGAATTGCAGGCGCTTCCGGCCATTGTCCAGGCGAAGATGATCAG
GCAATTAGACAAGTTACGCCAAAATCCCACCGCGCTGAGAGAACCTGATAGTAAACCGCTGGGGCAGGGGCTATTCGAAA
TTCGGGCGTTAGGTTCGGTACAGGGGCGGGGGATTTACGTTTTTCAGCAAGGCAAGACGCTCTTTCTGCTACGGGTTTTT
GTCAAGAAAACGCAAAAAACCCCGTCATCGGAAATTCGCCTGGCGCTGAAGCGATTAGAGGAGATGCGCAATGAGTAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10810.49 Da        Isoelectric Point: 10.2213

>AT42509 WP_049013658.1 NZ_AP026420:c3842178-3841891 [Klebsiella quasipneumoniae subsp. quasipneumoniae]
MSKKIIDWDTLKTELLSQPEVQAAFDAQERQHRLRTMLAQWREQAGLTRAQVAQRMGVSAPTVSRMEANITRASLDTLTR
YALACGIKHPQVLLY

Download         Length: 288 bp

>AT42509 NZ_AP026420:c3842178-3841891 [Klebsiella quasipneumoniae subsp. quasipneumoniae]
ATGAGTAAAAAGATCATTGACTGGGATACGTTAAAAACGGAACTGCTCAGCCAGCCTGAGGTTCAGGCTGCGTTCGATGC
GCAAGAACGTCAACATCGATTACGTACTATGCTGGCGCAATGGCGCGAGCAGGCGGGGCTGACCCGAGCCCAGGTGGCGC
AGAGGATGGGGGTGAGTGCGCCAACGGTCTCCAGAATGGAAGCCAATATCACCCGCGCCAGTCTGGATACCTTAACGCGA
TACGCGTTAGCCTGCGGTATAAAGCACCCGCAAGTTTTACTTTATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References