Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 3842054..3842651 Replicon chromosome
Accession NZ_AP026407
Organism Klebsiella quasipneumoniae subsp. quasipneumoniae strain KAM644

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag P4I75_RS18845 Protein ID WP_049013659.1
Coordinates 3842334..3842651 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag P4I75_RS18840 Protein ID WP_049013658.1
Coordinates 3842054..3842341 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P4I75_RS18810 (3838242) 3838242..3838490 + 249 WP_002893037.1 DUF1158 domain-containing protein -
P4I75_RS18815 (3838508) 3838508..3838849 - 342 WP_004202492.1 RamA family antibiotic efflux transcriptional regulator -
P4I75_RS18820 (3838880) 3838880..3839995 - 1116 WP_181075128.1 MBL fold metallo-hydrolase -
P4I75_RS18825 (3840175) 3840175..3840759 + 585 WP_023288732.1 TetR/AcrR family transcriptional regulator -
P4I75_RS18830 (3840756) 3840756..3841124 + 369 WP_276097403.1 MmcQ/YjbR family DNA-binding protein -
P4I75_RS18835 (3841244) 3841244..3841897 + 654 WP_023288731.1 oxygen-insensitive NAD(P)H nitroreductase -
P4I75_RS18840 (3842054) 3842054..3842341 - 288 WP_049013658.1 helix-turn-helix transcriptional regulator Antitoxin
P4I75_RS18845 (3842334) 3842334..3842651 - 318 WP_049013659.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
P4I75_RS18850 (3842836) 3842836..3843879 - 1044 WP_261901673.1 DUF2157 domain-containing protein -
P4I75_RS18855 (3844224) 3844224..3845090 - 867 WP_023288725.1 helix-turn-helix transcriptional regulator -
P4I75_RS18860 (3845199) 3845199..3846626 + 1428 WP_048296961.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-100)

Antitoxin

Cro/C1-type helix-turn-helix domain

(38-88)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12102.38 Da        Isoelectric Point: 11.2767

>T42492 WP_049013659.1 NZ_AP026407:c3842651-3842334 [Klebsiella quasipneumoniae subsp. quasipneumoniae]
MFRMVVHVDVKKELQALPAIVQAKMIRQLDKLRQNPTALREPDSKPLGQGLFEIRALGSVQGRGIYVFQQGKTLFLLRVF
VKKTQKTPSSEIRLALKRLEEMRNE

Download         Length: 318 bp

>T42492 NZ_AP026407:c3842651-3842334 [Klebsiella quasipneumoniae subsp. quasipneumoniae]
ATGTTCAGAATGGTTGTGCACGTGGACGTTAAAAAGGAATTGCAGGCGCTTCCGGCCATTGTCCAGGCGAAGATGATCAG
GCAATTAGACAAGTTACGCCAAAATCCCACCGCGCTGAGAGAACCTGATAGTAAACCGCTGGGGCAGGGGCTATTCGAAA
TTCGGGCGTTAGGTTCGGTACAGGGGCGGGGGATTTACGTTTTTCAGCAAGGCAAGACGCTCTTTCTGCTACGGGTTTTT
GTCAAGAAAACGCAAAAAACCCCGTCATCGGAAATTCGCCTGGCGCTGAAGCGATTAGAGGAGATGCGCAATGAGTAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10810.49 Da        Isoelectric Point: 10.2213

>AT42492 WP_049013658.1 NZ_AP026407:c3842341-3842054 [Klebsiella quasipneumoniae subsp. quasipneumoniae]
MSKKIIDWDTLKTELLSQPEVQAAFDAQERQHRLRTMLAQWREQAGLTRAQVAQRMGVSAPTVSRMEANITRASLDTLTR
YALACGIKHPQVLLY

Download         Length: 288 bp

>AT42492 NZ_AP026407:c3842341-3842054 [Klebsiella quasipneumoniae subsp. quasipneumoniae]
ATGAGTAAAAAGATCATTGACTGGGATACGTTAAAAACGGAACTGCTCAGCCAGCCTGAGGTTCAGGCTGCGTTCGATGC
GCAAGAACGTCAACATCGATTACGTACTATGCTGGCGCAATGGCGCGAGCAGGCGGGGCTGACCCGAGCCCAGGTGGCGC
AGAGGATGGGGGTGAGTGCGCCAACGGTCTCCAGAATGGAAGCCAATATCACCCGCGCCAGTCTGGATACCTTAACGCGA
TACGCGTTAGCCTGCGGTATAAAGCACCCGCAAGTTTTACTTTATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References