42451

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) symE-agrB/SymE(toxin)
Location 5361285..5361697 Replicon chromosome
Accession NZ_AP026118
Organism Escherichia coli strain CEC13004

Toxin (Protein)


Gene name symE Uniprot ID Q8FA88
Locus tag OO879_RS26615 Protein ID WP_000132630.1
Coordinates 5361285..5361626 (-) Length 114 a.a.

Antitoxin (RNA)


Gene name agrB
Locus tag -
Coordinates 5361621..5361697 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OO879_RS27490 (5356853) 5356853..5357053 + 201 WP_001310455.1 hypothetical protein -
OO879_RS26595 (5357296) 5357296..5358708 - 1413 WP_000199295.1 PLP-dependent aminotransferase family protein -
OO879_RS26600 (5358885) 5358885..5359049 + 165 WP_000394274.1 DUF1127 domain-containing protein -
OO879_RS26605 (5359146) 5359146..5360027 + 882 WP_001304007.1 DUF262 domain-containing protein -
OO879_RS26610 (5360075) 5360075..5361238 + 1164 WP_001304006.1 DUF1524 domain-containing protein -
OO879_RS26615 (5361285) 5361285..5361626 - 342 WP_000132630.1 endoribonuclease SymE Toxin
- (5361621) 5361621..5361697 + 77 NuclAT_14 - Antitoxin
- (5361621) 5361621..5361697 + 77 NuclAT_14 - Antitoxin
- (5361621) 5361621..5361697 + 77 NuclAT_14 - Antitoxin
- (5361621) 5361621..5361697 + 77 NuclAT_14 - Antitoxin
- (5361621) 5361621..5361697 + 77 NuclAT_15 - Antitoxin
- (5361621) 5361621..5361697 + 77 NuclAT_15 - Antitoxin
- (5361621) 5361621..5361697 + 77 NuclAT_15 - Antitoxin
- (5361621) 5361621..5361697 + 77 NuclAT_15 - Antitoxin
OO879_RS26620 (5361847) 5361847..5363601 - 1755 WP_000110082.1 restriction endonuclease subunit S -
OO879_RS26625 (5363601) 5363601..5365070 - 1470 WP_001302468.1 type I restriction-modification system subunit M -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 5350778..5369498 18720


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(20-71)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12294.13 Da        Isoelectric Point: 8.4982

>T42451 WP_000132630.1 NZ_AP026118:c5361626-5361285 [Escherichia coli]
MTDTHSIAQPFEAEVSPANNRQLTVSYASRYPDYSRIPAITLKGQWLEAAGFATGTVVDVKVMEGCIVLTAQPPAAAESE
LMQSLRQVCKLSARKQRQVQEFIGVIAGKQKVA

Download         Length: 342 bp

>T42451 NZ_AP026118:c5361626-5361285 [Escherichia coli]
ATGACTGATACGCATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCCCCGGCAAATAACCGTCAATTAACCGTGAGTTA
TGCGAGTCGTTACCCGGATTACAGCCGTATTCCCGCCATCACCCTGAAAGGTCAGTGGCTGGAAGCCGCCGGTTTTGCCA
CCGGCACGGTGGTAGATGTCAAAGTGATGGAAGGCTGTATTGTCCTCACCGCCCAACCACCCGCCGCCGCCGAGAGCGAA
CTGATGCAGTCGCTGCGCCAGGTGTGCAAGCTGTCGGCGCGTAAACAAAGGCAGGTGCAGGAGTTTATTGGGGTGATTGC
GGGTAAACAGAAAGTTGCCTGA

Antitoxin


Download         Length: 77 bp

>AT42451 NZ_AP026118:5361621-5361697 [Escherichia coli]
AGTCATAACTGCTATTCCCTATAAATAGTGATTGTGATTAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y5T0

Antitoxin

Download structure file

References