Detailed information of TA system TA042429

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 2030394..2030619
• Replicon: chromosome
• Accession: NZ_AP026118
• Organism: Escherichia coli strain CEC13004

Toxin (Protein)

• Gene name: hokW
• Uniprot ID: A0A1Q4PF16
• Locus tag: OO879_RS09915
• Protein ID: WP_000813258.1
• Coordinates: 2030394..2030549 (-)
• Length: 52 a.a.

Antitoxin (RNA)

Gene name	sokW
Locus tag	-
Coordinates	2030561..2030619 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
OO879_RS09865	2025396..2025824	-	429	WP_001303509.1	tellurite resistance protein	-
OO879_RS09880	2026279..2026992	-	714	WP_000301797.1	helix-turn-helix domain-containing protein	-
OO879_RS09885	2027128..2027325	-	198	WP_000917763.1	hypothetical protein	-
OO879_RS09890	2027550..2028104	-	555	WP_000640035.1	DUF1133 family protein	-
OO879_RS09895	2028167..2028472	-	306	WP_001217444.1	RusA family crossover junction endodeoxyribonuclease	-
OO879_RS09900	2028485..2029534	-	1050	WP_001265229.1	DUF968 domain-containing protein	-
OO879_RS09905	2029536..2029808	-	273	WP_000191870.1	hypothetical protein	-
OO879_RS09910	2029930..2030274	-	345	WP_000756596.1	YgiW/YdeI family stress tolerance OB fold protein	-
OO879_RS09915	2030394..2030549	-	156	WP_000813258.1	Hok/Gef family protein	Toxin
-	2030561..2030619	+	59	-	-	Antitoxin
OO879_RS09920	2030840..2031397	-	558	WP_000104474.1	DUF551 domain-containing protein	-
OO879_RS09925	2031399..2031617	-	219	WP_000683609.1	DUF4014 family protein	-
OO879_RS09930	2031745..2032056	-	312	WP_001289673.1	hypothetical protein	-
OO879_RS09935	2032049..2032276	-	228	WP_000699809.1	hypothetical protein	-
OO879_RS09940	2032273..2032554	-	282	WP_000603384.1	DNA-binding protein	-
OO879_RS09945	2032587..2033303	-	717	WP_000450627.1	DUF1627 domain-containing protein	-
OO879_RS09950	2033337..2033798	-	462	WP_000139447.1	replication protein P	-
OO879_RS09955	2033791..2034834	-	1044	WP_001262402.1	DnaT-like ssDNA-binding domain-containing protein	-
OO879_RS09960	2034903..2035328	-	426	WP_000693878.1	toxin YdaT family protein	-
OO879_RS09965	2035312..2035554	-	243	WP_000747948.1	Cro/CI family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	nleG7'	1992947..2099005	106058

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 52 a.a.
• Molecular weight: 5767.95 Da
• Isoelectric Point: 7.7942

>T42429 WP_000813258.1 NZ_AP026118:c2030549-2030394 [Escherichia coli]
MKQQKAMLIALIVICLTVIVTALVTRKDLCEVRIRTGQTEVAVFVDYESEK

Nucleotide

• Length: 156 bp

>T42429 NZ_AP026118:c2030549-2030394 [Escherichia coli]
ATGAAGCAGCAAAAGGCGATGTTAATCGCCCTGATCGTCATCTGTTTAACCGTCATAGTGACGGCACTGGTAACGAGGAA
AGACCTCTGCGAGGTGCGAATCCGAACCGGTCAGACGGAGGTCGCTGTCTTCGTAGACTACGAATCTGAGAAGTAA

Antitoxin

Nucleotide

• Length: 59 bp

>AT42429 NZ_AP026118:2030561-2030619 [Escherichia coli]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACATGTGTTCAGCATGGATTGAGCCTCA

Structures

Toxin

• AlphaFold DB: A0A1Q4PF16

Antitoxin