Detailed information of TA system TA042423

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 1180720..1180945
• Replicon: chromosome
• Accession: NZ_AP026118
• Organism: Escherichia coli strain CEC13004

Toxin (Protein)

• Gene name: hokW
• Uniprot ID: -
• Locus tag: OO879_RS05485
• Protein ID: WP_000813263.1
• Coordinates: 1180790..1180945 (+)
• Length: 52 a.a.

Antitoxin (RNA)

Gene name	sokW
Locus tag	-
Coordinates	1180720..1180778 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
OO879_RS05455	1175995..1177086	+	1092	WP_001205823.1	hypothetical protein	-
OO879_RS05460	1177093..1177839	+	747	WP_000788745.1	ATP-binding protein	-
OO879_RS05465	1177861..1178631	+	771	WP_000450992.1	DUF1627 domain-containing protein	-
OO879_RS05470	1178647..1179060	+	414	WP_001151233.1	DUF977 family protein	-
OO879_RS05475	1179412..1180185	-	774	WP_000160654.1	alpha/beta hydrolase	-
-	1180720..1180778	-	59	-	-	Antitoxin
OO879_RS05485	1180790..1180945	+	156	WP_000813263.1	type I toxin-antitoxin system toxin HokD	Toxin
OO879_RS05490	1181113..1181391	+	279	WP_001341388.1	hypothetical protein	-
OO879_RS05495	1181393..1182442	+	1050	WP_001265172.1	DUF968 domain-containing protein	-
OO879_RS05500	1182455..1182826	+	372	WP_001217436.1	RusA family crossover junction endodeoxyribonuclease	-
OO879_RS05505	1182816..1183187	+	372	WP_000090264.1	antiterminator Q family protein	-
OO879_RS05510	1183339..1184157	+	819	WP_000265265.1	CPBP family intramembrane metalloprotease	-
OO879_RS05515	1184444..1184640	+	197	Protein_1080	TrmB family transcriptional regulator	-
OO879_RS05520	1184778..1185491	+	714	WP_000261909.1	helix-turn-helix domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 52 a.a.
• Molecular weight: 5722.86 Da
• Isoelectric Point: 6.1531

>T42423 WP_000813263.1 NZ_AP026118:1180790-1180945 [Escherichia coli]
MKQQKAMLIALIVICLTVIVTALVTRKDLCEVRVRTGQTEVAVFTAYEPEE

Nucleotide

• Length: 156 bp

>T42423 NZ_AP026118:1180790-1180945 [Escherichia coli]
ATGAAGCAGCAAAAGGCGATGTTAATCGCCCTGATCGTCATCTGTTTAACCGTCATAGTGACGGCACTGGTAACGAGGAA
AGACCTCTGCGAGGTACGAGTCCGAACCGGCCAGACGGAGGTCGCTGTCTTCACAGCTTACGAACCTGAGGAGTAA

Antitoxin

Nucleotide

• Length: 59 bp

>AT42423 NZ_AP026118:c1180778-1180720 [Escherichia coli]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTAGATTTGCCGTTCATAGATTGAGCCTCA

Structures

Antitoxin