42412

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) symE-agrB/SymE(toxin)
Location 5324277..5324689 Replicon chromosome
Accession NZ_AP026116
Organism Escherichia coli strain CEC13002

Toxin (Protein)


Gene name symE Uniprot ID Q8FA88
Locus tag OO850_RS26430 Protein ID WP_000132630.1
Coordinates 5324277..5324618 (-) Length 114 a.a.

Antitoxin (RNA)


Gene name agrB
Locus tag -
Coordinates 5324613..5324689 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OO850_RS27305 (5319845) 5319845..5320045 + 201 WP_001310455.1 hypothetical protein -
OO850_RS26410 (5320288) 5320288..5321700 - 1413 WP_000199295.1 PLP-dependent aminotransferase family protein -
OO850_RS26415 (5321877) 5321877..5322041 + 165 WP_000394274.1 DUF1127 domain-containing protein -
OO850_RS26420 (5322138) 5322138..5323019 + 882 WP_001304007.1 DUF262 domain-containing protein -
OO850_RS26425 (5323067) 5323067..5324230 + 1164 WP_001304006.1 DUF1524 domain-containing protein -
OO850_RS26430 (5324277) 5324277..5324618 - 342 WP_000132630.1 endoribonuclease SymE Toxin
- (5324613) 5324613..5324689 + 77 NuclAT_14 - Antitoxin
- (5324613) 5324613..5324689 + 77 NuclAT_14 - Antitoxin
- (5324613) 5324613..5324689 + 77 NuclAT_14 - Antitoxin
- (5324613) 5324613..5324689 + 77 NuclAT_14 - Antitoxin
- (5324613) 5324613..5324689 + 77 NuclAT_15 - Antitoxin
- (5324613) 5324613..5324689 + 77 NuclAT_15 - Antitoxin
- (5324613) 5324613..5324689 + 77 NuclAT_15 - Antitoxin
- (5324613) 5324613..5324689 + 77 NuclAT_15 - Antitoxin
OO850_RS26435 (5324839) 5324839..5326593 - 1755 WP_264831542.1 restriction endonuclease subunit S -
OO850_RS26440 (5326593) 5326593..5328062 - 1470 WP_001302468.1 type I restriction-modification system subunit M -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 5313770..5332490 18720


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(20-71)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12294.13 Da        Isoelectric Point: 8.4982

>T42412 WP_000132630.1 NZ_AP026116:c5324618-5324277 [Escherichia coli]
MTDTHSIAQPFEAEVSPANNRQLTVSYASRYPDYSRIPAITLKGQWLEAAGFATGTVVDVKVMEGCIVLTAQPPAAAESE
LMQSLRQVCKLSARKQRQVQEFIGVIAGKQKVA

Download         Length: 342 bp

>T42412 NZ_AP026116:c5324618-5324277 [Escherichia coli]
ATGACTGATACGCATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCCCCGGCAAATAACCGTCAATTAACCGTGAGTTA
TGCGAGTCGTTACCCGGATTACAGCCGTATTCCCGCCATCACCCTGAAAGGTCAGTGGCTGGAAGCCGCCGGTTTTGCCA
CCGGCACGGTGGTAGATGTCAAAGTGATGGAAGGCTGTATTGTCCTCACCGCCCAACCACCCGCCGCCGCCGAGAGCGAA
CTGATGCAGTCGCTGCGCCAGGTGTGCAAGCTGTCGGCGCGTAAACAAAGGCAGGTGCAGGAGTTTATTGGGGTGATTGC
GGGTAAACAGAAAGTTGCCTGA

Antitoxin


Download         Length: 77 bp

>AT42412 NZ_AP026116:5324613-5324689 [Escherichia coli]
AGTCATAACTGCTATTCCCTATAAATAGTGATTGTGATTAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y5T0

Antitoxin

Download structure file

References