42377

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) symE-agrB/SymE(toxin)
Location 5270276..5270688 Replicon chromosome
Accession NZ_AP026114
Organism Escherichia coli strain CEC01302

Toxin (Protein)


Gene name symE Uniprot ID Q8FA88
Locus tag OO829_RS25955 Protein ID WP_000132630.1
Coordinates 5270276..5270617 (-) Length 114 a.a.

Antitoxin (RNA)


Gene name agrB
Locus tag -
Coordinates 5270612..5270688 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OO829_RS25935 (5266287) 5266287..5267699 - 1413 WP_000199295.1 PLP-dependent aminotransferase family protein -
OO829_RS25940 (5267876) 5267876..5268040 + 165 WP_000394274.1 DUF1127 domain-containing protein -
OO829_RS25945 (5268137) 5268137..5269018 + 882 WP_001304007.1 DUF262 domain-containing protein -
OO829_RS25950 (5269066) 5269066..5270229 + 1164 WP_001304006.1 DUF1524 domain-containing protein -
OO829_RS25955 (5270276) 5270276..5270617 - 342 WP_000132630.1 endoribonuclease SymE Toxin
- (5270612) 5270612..5270688 + 77 NuclAT_14 - Antitoxin
- (5270612) 5270612..5270688 + 77 NuclAT_14 - Antitoxin
- (5270612) 5270612..5270688 + 77 NuclAT_14 - Antitoxin
- (5270612) 5270612..5270688 + 77 NuclAT_14 - Antitoxin
- (5270612) 5270612..5270688 + 77 NuclAT_15 - Antitoxin
- (5270612) 5270612..5270688 + 77 NuclAT_15 - Antitoxin
- (5270612) 5270612..5270688 + 77 NuclAT_15 - Antitoxin
- (5270612) 5270612..5270688 + 77 NuclAT_15 - Antitoxin
OO829_RS25960 (5270838) 5270838..5272592 - 1755 WP_097336120.1 restriction endonuclease subunit S -
OO829_RS25965 (5272592) 5272592..5274061 - 1470 WP_001302468.1 type I restriction-modification system subunit M -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 5259794..5278489 18695


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(20-71)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12294.13 Da        Isoelectric Point: 8.4982

>T42377 WP_000132630.1 NZ_AP026114:c5270617-5270276 [Escherichia coli]
MTDTHSIAQPFEAEVSPANNRQLTVSYASRYPDYSRIPAITLKGQWLEAAGFATGTVVDVKVMEGCIVLTAQPPAAAESE
LMQSLRQVCKLSARKQRQVQEFIGVIAGKQKVA

Download         Length: 342 bp

>T42377 NZ_AP026114:c5270617-5270276 [Escherichia coli]
ATGACTGATACGCATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCCCCGGCAAATAACCGTCAATTAACCGTGAGTTA
TGCGAGTCGTTACCCGGATTACAGCCGTATTCCCGCCATCACCCTGAAAGGTCAGTGGCTGGAAGCCGCCGGTTTTGCCA
CCGGCACGGTGGTAGATGTCAAAGTGATGGAAGGCTGTATTGTCCTCACCGCCCAACCACCCGCCGCCGCCGAGAGCGAA
CTGATGCAGTCGCTGCGCCAGGTGTGCAAGCTGTCGGCGCGTAAACAAAGGCAGGTGCAGGAGTTTATTGGGGTGATTGC
GGGTAAACAGAAAGTTGCCTGA

Antitoxin


Download         Length: 77 bp

>AT42377 NZ_AP026114:5270612-5270688 [Escherichia coli]
AGTCATAACTGCTATTCCCTATAAATAGTGATTGTGATTAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y5T0

Antitoxin

Download structure file

References