Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | I | Classification (family/domain) | symE-agrB/SymE(toxin) |
Location | 5420325..5420737 | Replicon | chromosome |
Accession | NZ_AP026112 | ||
Organism | Escherichia coli strain CEC03102 |
Toxin (Protein)
Gene name | symE | Uniprot ID | Q8FA88 |
Locus tag | OO877_RS26990 | Protein ID | WP_000132630.1 |
Coordinates | 5420325..5420666 (-) | Length | 114 a.a. |
Antitoxin (RNA)
Gene name | agrB | ||
Locus tag | - | ||
Coordinates | 5420661..5420737 (+) |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
OO877_RS26970 (5416336) | 5416336..5417748 | - | 1413 | WP_000199295.1 | PLP-dependent aminotransferase family protein | - |
OO877_RS26975 (5417925) | 5417925..5418089 | + | 165 | WP_000394274.1 | DUF1127 domain-containing protein | - |
OO877_RS26980 (5418186) | 5418186..5419067 | + | 882 | WP_001304007.1 | DUF262 domain-containing protein | - |
OO877_RS26985 (5419115) | 5419115..5420278 | + | 1164 | WP_001304006.1 | DUF1524 domain-containing protein | - |
OO877_RS26990 (5420325) | 5420325..5420666 | - | 342 | WP_000132630.1 | endoribonuclease SymE | Toxin |
- (5420661) | 5420661..5420737 | + | 77 | NuclAT_14 | - | Antitoxin |
- (5420661) | 5420661..5420737 | + | 77 | NuclAT_14 | - | Antitoxin |
- (5420661) | 5420661..5420737 | + | 77 | NuclAT_14 | - | Antitoxin |
- (5420661) | 5420661..5420737 | + | 77 | NuclAT_14 | - | Antitoxin |
- (5420661) | 5420661..5420737 | + | 77 | NuclAT_15 | - | Antitoxin |
- (5420661) | 5420661..5420737 | + | 77 | NuclAT_15 | - | Antitoxin |
- (5420661) | 5420661..5420737 | + | 77 | NuclAT_15 | - | Antitoxin |
- (5420661) | 5420661..5420737 | + | 77 | NuclAT_15 | - | Antitoxin |
OO877_RS26995 (5420887) | 5420887..5422641 | - | 1755 | WP_000110082.1 | restriction endonuclease subunit S | - |
OO877_RS27000 (5422641) | 5422641..5424110 | - | 1470 | WP_001302468.1 | type I restriction-modification system subunit M | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
inside | Genomic island | - | - | 5409843..5428538 | 18695 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 114 a.a. Molecular weight: 12294.13 Da Isoelectric Point: 8.4982
>T42344 WP_000132630.1 NZ_AP026112:c5420666-5420325 [Escherichia coli]
MTDTHSIAQPFEAEVSPANNRQLTVSYASRYPDYSRIPAITLKGQWLEAAGFATGTVVDVKVMEGCIVLTAQPPAAAESE
LMQSLRQVCKLSARKQRQVQEFIGVIAGKQKVA
MTDTHSIAQPFEAEVSPANNRQLTVSYASRYPDYSRIPAITLKGQWLEAAGFATGTVVDVKVMEGCIVLTAQPPAAAESE
LMQSLRQVCKLSARKQRQVQEFIGVIAGKQKVA
Download Length: 342 bp
>T42344 NZ_AP026112:c5420666-5420325 [Escherichia coli]
ATGACTGATACGCATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCCCCGGCAAATAACCGTCAATTAACCGTGAGTTA
TGCGAGTCGTTACCCGGATTACAGCCGTATTCCCGCCATCACCCTGAAAGGTCAGTGGCTGGAAGCCGCCGGTTTTGCCA
CCGGCACGGTGGTAGATGTCAAAGTGATGGAAGGCTGTATTGTCCTCACCGCCCAACCACCCGCCGCCGCCGAGAGCGAA
CTGATGCAGTCGCTGCGCCAGGTGTGCAAGCTGTCGGCGCGTAAACAAAGGCAGGTGCAGGAGTTTATTGGGGTGATTGC
GGGTAAACAGAAAGTTGCCTGA
ATGACTGATACGCATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCCCCGGCAAATAACCGTCAATTAACCGTGAGTTA
TGCGAGTCGTTACCCGGATTACAGCCGTATTCCCGCCATCACCCTGAAAGGTCAGTGGCTGGAAGCCGCCGGTTTTGCCA
CCGGCACGGTGGTAGATGTCAAAGTGATGGAAGGCTGTATTGTCCTCACCGCCCAACCACCCGCCGCCGCCGAGAGCGAA
CTGATGCAGTCGCTGCGCCAGGTGTGCAAGCTGTCGGCGCGTAAACAAAGGCAGGTGCAGGAGTTTATTGGGGTGATTGC
GGGTAAACAGAAAGTTGCCTGA
Antitoxin
Download Length: 77 bp
>AT42344 NZ_AP026112:5420661-5420737 [Escherichia coli]
AGTCATAACTGCTATTCCCTATAAATAGTGATTGTGATTAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT
AGTCATAACTGCTATTCCCTATAAATAGTGATTGTGATTAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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