Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) symE-agrB/SymE(toxin)
Location 5420325..5420737 Replicon chromosome
Accession NZ_AP026112
Organism Escherichia coli strain CEC03102

Toxin (Protein)


Gene name symE Uniprot ID Q8FA88
Locus tag OO877_RS26990 Protein ID WP_000132630.1
Coordinates 5420325..5420666 (-) Length 114 a.a.

Antitoxin (RNA)


Gene name agrB
Locus tag -
Coordinates 5420661..5420737 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OO877_RS26970 (5416336) 5416336..5417748 - 1413 WP_000199295.1 PLP-dependent aminotransferase family protein -
OO877_RS26975 (5417925) 5417925..5418089 + 165 WP_000394274.1 DUF1127 domain-containing protein -
OO877_RS26980 (5418186) 5418186..5419067 + 882 WP_001304007.1 DUF262 domain-containing protein -
OO877_RS26985 (5419115) 5419115..5420278 + 1164 WP_001304006.1 DUF1524 domain-containing protein -
OO877_RS26990 (5420325) 5420325..5420666 - 342 WP_000132630.1 endoribonuclease SymE Toxin
- (5420661) 5420661..5420737 + 77 NuclAT_14 - Antitoxin
- (5420661) 5420661..5420737 + 77 NuclAT_14 - Antitoxin
- (5420661) 5420661..5420737 + 77 NuclAT_14 - Antitoxin
- (5420661) 5420661..5420737 + 77 NuclAT_14 - Antitoxin
- (5420661) 5420661..5420737 + 77 NuclAT_15 - Antitoxin
- (5420661) 5420661..5420737 + 77 NuclAT_15 - Antitoxin
- (5420661) 5420661..5420737 + 77 NuclAT_15 - Antitoxin
- (5420661) 5420661..5420737 + 77 NuclAT_15 - Antitoxin
OO877_RS26995 (5420887) 5420887..5422641 - 1755 WP_000110082.1 restriction endonuclease subunit S -
OO877_RS27000 (5422641) 5422641..5424110 - 1470 WP_001302468.1 type I restriction-modification system subunit M -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 5409843..5428538 18695


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(20-71)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12294.13 Da        Isoelectric Point: 8.4982

>T42344 WP_000132630.1 NZ_AP026112:c5420666-5420325 [Escherichia coli]
MTDTHSIAQPFEAEVSPANNRQLTVSYASRYPDYSRIPAITLKGQWLEAAGFATGTVVDVKVMEGCIVLTAQPPAAAESE
LMQSLRQVCKLSARKQRQVQEFIGVIAGKQKVA

Download         Length: 342 bp

>T42344 NZ_AP026112:c5420666-5420325 [Escherichia coli]
ATGACTGATACGCATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCCCCGGCAAATAACCGTCAATTAACCGTGAGTTA
TGCGAGTCGTTACCCGGATTACAGCCGTATTCCCGCCATCACCCTGAAAGGTCAGTGGCTGGAAGCCGCCGGTTTTGCCA
CCGGCACGGTGGTAGATGTCAAAGTGATGGAAGGCTGTATTGTCCTCACCGCCCAACCACCCGCCGCCGCCGAGAGCGAA
CTGATGCAGTCGCTGCGCCAGGTGTGCAAGCTGTCGGCGCGTAAACAAAGGCAGGTGCAGGAGTTTATTGGGGTGATTGC
GGGTAAACAGAAAGTTGCCTGA

Antitoxin


Download         Length: 77 bp

>AT42344 NZ_AP026112:5420661-5420737 [Escherichia coli]
AGTCATAACTGCTATTCCCTATAAATAGTGATTGTGATTAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y5T0

Antitoxin

Download structure file

References