Detailed information of TA system TA042316

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 1178396..1178621
• Replicon: chromosome
• Accession: NZ_AP026112
• Organism: Escherichia coli strain CEC03102

Toxin (Protein)

• Gene name: hokW
• Uniprot ID: -
• Locus tag: OO877_RS05470
• Protein ID: WP_000813263.1
• Coordinates: 1178466..1178621 (+)
• Length: 52 a.a.

Antitoxin (RNA)

Gene name	sokW
Locus tag	-
Coordinates	1178396..1178454 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
OO877_RS05440	1173671..1174762	+	1092	WP_001205823.1	hypothetical protein	-
OO877_RS05445	1174769..1175515	+	747	WP_000788745.1	ATP-binding protein	-
OO877_RS05450	1175537..1176307	+	771	WP_000450992.1	DUF1627 domain-containing protein	-
OO877_RS05455	1176323..1176736	+	414	WP_001151233.1	DUF977 family protein	-
OO877_RS05460	1177088..1177861	-	774	WP_000160654.1	alpha/beta hydrolase	-
-	1178396..1178454	-	59	-	-	Antitoxin
OO877_RS05470	1178466..1178621	+	156	WP_000813263.1	type I toxin-antitoxin system toxin HokD	Toxin
OO877_RS05475	1178789..1179067	+	279	WP_001341388.1	hypothetical protein	-
OO877_RS05480	1179069..1180118	+	1050	WP_001265172.1	DUF968 domain-containing protein	-
OO877_RS05485	1180131..1180502	+	372	WP_001217436.1	RusA family crossover junction endodeoxyribonuclease	-
OO877_RS05490	1180492..1180863	+	372	WP_000090264.1	antiterminator Q family protein	-
OO877_RS05495	1181015..1181833	+	819	WP_000265265.1	CPBP family intramembrane metalloprotease	-
OO877_RS05500	1182120..1182316	+	197	Protein_1077	TrmB family transcriptional regulator	-
OO877_RS05505	1182454..1183167	+	714	WP_000261909.1	helix-turn-helix domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 52 a.a.
• Molecular weight: 5722.86 Da
• Isoelectric Point: 6.1531

>T42316 WP_000813263.1 NZ_AP026112:1178466-1178621 [Escherichia coli]
MKQQKAMLIALIVICLTVIVTALVTRKDLCEVRVRTGQTEVAVFTAYEPEE

Nucleotide

• Length: 156 bp

>T42316 NZ_AP026112:1178466-1178621 [Escherichia coli]
ATGAAGCAGCAAAAGGCGATGTTAATCGCCCTGATCGTCATCTGTTTAACCGTCATAGTGACGGCACTGGTAACGAGGAA
AGACCTCTGCGAGGTACGAGTCCGAACCGGCCAGACGGAGGTCGCTGTCTTCACAGCTTACGAACCTGAGGAGTAA

Antitoxin

Nucleotide

• Length: 59 bp

>AT42316 NZ_AP026112:c1178454-1178396 [Escherichia coli]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTAGATTTGCCGTTCATAGATTGAGCCTCA

Structures

Antitoxin