Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) symE-agrB/SymE(toxin)
Location 5334478..5334890 Replicon chromosome
Accession NZ_AP026110
Organism Escherichia coli strain CEC08123

Toxin (Protein)


Gene name symE Uniprot ID Q8FA88
Locus tag OO855_RS26415 Protein ID WP_000132630.1
Coordinates 5334478..5334819 (-) Length 114 a.a.

Antitoxin (RNA)


Gene name agrB
Locus tag -
Coordinates 5334814..5334890 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OO855_RS26395 (5330489) 5330489..5331901 - 1413 WP_000199295.1 PLP-dependent aminotransferase family protein -
OO855_RS26400 (5332078) 5332078..5332242 + 165 WP_000394274.1 DUF1127 domain-containing protein -
OO855_RS26405 (5332339) 5332339..5333220 + 882 WP_001304007.1 DUF262 domain-containing protein -
OO855_RS26410 (5333268) 5333268..5334431 + 1164 WP_001304006.1 DUF1524 domain-containing protein -
OO855_RS26415 (5334478) 5334478..5334819 - 342 WP_000132630.1 endoribonuclease SymE Toxin
- (5334814) 5334814..5334890 + 77 NuclAT_14 - Antitoxin
- (5334814) 5334814..5334890 + 77 NuclAT_14 - Antitoxin
- (5334814) 5334814..5334890 + 77 NuclAT_14 - Antitoxin
- (5334814) 5334814..5334890 + 77 NuclAT_14 - Antitoxin
- (5334814) 5334814..5334890 + 77 NuclAT_15 - Antitoxin
- (5334814) 5334814..5334890 + 77 NuclAT_15 - Antitoxin
- (5334814) 5334814..5334890 + 77 NuclAT_15 - Antitoxin
- (5334814) 5334814..5334890 + 77 NuclAT_15 - Antitoxin
OO855_RS26420 (5335040) 5335040..5336794 - 1755 WP_000110082.1 restriction endonuclease subunit S -
OO855_RS26425 (5336794) 5336794..5338263 - 1470 WP_001302468.1 type I restriction-modification system subunit M -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 5323996..5342691 18695


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(20-71)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12294.13 Da        Isoelectric Point: 8.4982

>T42305 WP_000132630.1 NZ_AP026110:c5334819-5334478 [Escherichia coli]
MTDTHSIAQPFEAEVSPANNRQLTVSYASRYPDYSRIPAITLKGQWLEAAGFATGTVVDVKVMEGCIVLTAQPPAAAESE
LMQSLRQVCKLSARKQRQVQEFIGVIAGKQKVA

Download         Length: 342 bp

>T42305 NZ_AP026110:c5334819-5334478 [Escherichia coli]
ATGACTGATACGCATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCCCCGGCAAATAACCGTCAATTAACCGTGAGTTA
TGCGAGTCGTTACCCGGATTACAGCCGTATTCCCGCCATCACCCTGAAAGGTCAGTGGCTGGAAGCCGCCGGTTTTGCCA
CCGGCACGGTGGTAGATGTCAAAGTGATGGAAGGCTGTATTGTCCTCACCGCCCAACCACCCGCCGCCGCCGAGAGCGAA
CTGATGCAGTCGCTGCGCCAGGTGTGCAAGCTGTCGGCGCGTAAACAAAGGCAGGTGCAGGAGTTTATTGGGGTGATTGC
GGGTAAACAGAAAGTTGCCTGA

Antitoxin


Download         Length: 77 bp

>AT42305 NZ_AP026110:5334814-5334890 [Escherichia coli]
AGTCATAACTGCTATTCCCTATAAATAGTGATTGTGATTAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y5T0

Antitoxin

Download structure file

References