Detailed information of TA system TA042290

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 1721578..1721803
• Replicon: chromosome
• Accession: NZ_AP026110
• Organism: Escherichia coli strain CEC08123

Toxin (Protein)

• Gene name: hokW
• Uniprot ID: A0A1Q4PF16
• Locus tag: OO855_RS08535
• Protein ID: WP_000813258.1
• Coordinates: 1721648..1721803 (+)
• Length: 52 a.a.

Antitoxin (RNA)

Gene name	sokW
Locus tag	-
Coordinates	1721578..1721636 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
OO855_RS08485	1716630..1716873	+	244	Protein_1663	Cro/CI family transcriptional regulator	-
OO855_RS08490	1716857..1717282	+	426	WP_000693878.1	toxin YdaT family protein	-
OO855_RS08495	1717351..1718406	+	1056	WP_001356791.1	DnaT-like ssDNA-binding domain-containing protein	-
OO855_RS08500	1718399..1718860	+	462	WP_000139447.1	replication protein P	-
OO855_RS08505	1718894..1719610	+	717	WP_000450627.1	DUF1627 domain-containing protein	-
OO855_RS08510	1719643..1719924	+	282	WP_000603384.1	DNA-binding protein	-
OO855_RS08515	1719921..1720148	+	228	WP_000699809.1	hypothetical protein	-
OO855_RS08520	1720141..1720452	+	312	WP_001289673.1	hypothetical protein	-
OO855_RS08525	1720580..1720798	+	219	WP_000683609.1	DUF4014 family protein	-
OO855_RS08530	1720800..1721357	+	558	WP_000104474.1	DUF551 domain-containing protein	-
-	1721578..1721636	-	59	-	-	Antitoxin
OO855_RS08535	1721648..1721803	+	156	WP_000813258.1	Hok/Gef family protein	Toxin
OO855_RS08540	1721923..1722267	+	345	WP_000756596.1	YgiW/YdeI family stress tolerance OB fold protein	-
OO855_RS08545	1722389..1722661	+	273	WP_000191871.1	hypothetical protein	-
OO855_RS08550	1722663..1723712	+	1050	WP_001265229.1	DUF968 domain-containing protein	-
OO855_RS08555	1723725..1724030	+	306	WP_001217444.1	RusA family crossover junction endodeoxyribonuclease	-
OO855_RS08560	1724093..1724647	+	555	WP_000640035.1	DUF1133 family protein	-
OO855_RS08565	1724872..1725069	+	198	WP_000917763.1	hypothetical protein	-
OO855_RS08570	1725205..1725918	+	714	WP_000301797.1	helix-turn-helix domain-containing protein	-
OO855_RS08585	1726369..1726800	+	432	WP_001302123.1	tellurite resistance protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	nleG7'	1662216..1759250	97034

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 52 a.a.
• Molecular weight: 5767.95 Da
• Isoelectric Point: 7.7942

>T42290 WP_000813258.1 NZ_AP026110:1721648-1721803 [Escherichia coli]
MKQQKAMLIALIVICLTVIVTALVTRKDLCEVRIRTGQTEVAVFVDYESEK

Nucleotide

• Length: 156 bp

>T42290 NZ_AP026110:1721648-1721803 [Escherichia coli]
ATGAAGCAGCAAAAGGCGATGTTAATCGCCCTGATCGTCATCTGTTTAACCGTCATAGTGACGGCACTGGTAACGAGGAA
AGACCTCTGCGAGGTGCGAATCCGAACCGGTCAGACGGAGGTCGCTGTCTTCGTAGACTACGAATCTGAGAAGTAA

Antitoxin

Nucleotide

• Length: 59 bp

>AT42290 NZ_AP026110:c1721636-1721578 [Escherichia coli]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACATGTGTTCAGCATGGATTGAGCCTCA

Structures

Toxin

• AlphaFold DB: A0A1Q4PF16

Antitoxin