Detailed information of TA system TA042279

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 1178365..1178590
• Replicon: chromosome
• Accession: NZ_AP026110
• Organism: Escherichia coli strain CEC08123

Toxin (Protein)

• Gene name: hokW
• Uniprot ID: -
• Locus tag: OO855_RS05475
• Protein ID: WP_000813263.1
• Coordinates: 1178435..1178590 (+)
• Length: 52 a.a.

Antitoxin (RNA)

Gene name	sokW
Locus tag	-
Coordinates	1178365..1178423 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
OO855_RS05445	1173640..1174731	+	1092	WP_001205823.1	hypothetical protein	-
OO855_RS05450	1174738..1175484	+	747	WP_000788745.1	ATP-binding protein	-
OO855_RS05455	1175506..1176276	+	771	WP_000450992.1	DUF1627 domain-containing protein	-
OO855_RS05460	1176292..1176705	+	414	WP_001151233.1	DUF977 family protein	-
OO855_RS05465	1177057..1177830	-	774	WP_000160654.1	alpha/beta hydrolase	-
-	1178365..1178423	-	59	-	-	Antitoxin
OO855_RS05475	1178435..1178590	+	156	WP_000813263.1	type I toxin-antitoxin system toxin HokD	Toxin
OO855_RS05480	1178758..1179036	+	279	WP_001341388.1	hypothetical protein	-
OO855_RS05485	1179038..1180087	+	1050	WP_001265172.1	DUF968 domain-containing protein	-
OO855_RS05490	1180100..1180471	+	372	WP_001217436.1	RusA family crossover junction endodeoxyribonuclease	-
OO855_RS05495	1180461..1180832	+	372	WP_000090264.1	antiterminator Q family protein	-
OO855_RS05500	1180984..1181802	+	819	WP_000265265.1	CPBP family intramembrane metalloprotease	-
OO855_RS05505	1182089..1182285	+	197	Protein_1078	TrmB family transcriptional regulator	-
OO855_RS05510	1182423..1183136	+	714	WP_000261909.1	helix-turn-helix domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 52 a.a.
• Molecular weight: 5722.86 Da
• Isoelectric Point: 6.1531

>T42279 WP_000813263.1 NZ_AP026110:1178435-1178590 [Escherichia coli]
MKQQKAMLIALIVICLTVIVTALVTRKDLCEVRVRTGQTEVAVFTAYEPEE

Nucleotide

• Length: 156 bp

>T42279 NZ_AP026110:1178435-1178590 [Escherichia coli]
ATGAAGCAGCAAAAGGCGATGTTAATCGCCCTGATCGTCATCTGTTTAACCGTCATAGTGACGGCACTGGTAACGAGGAA
AGACCTCTGCGAGGTACGAGTCCGAACCGGCCAGACGGAGGTCGCTGTCTTCACAGCTTACGAACCTGAGGAGTAA

Antitoxin

Nucleotide

• Length: 59 bp

>AT42279 NZ_AP026110:c1178423-1178365 [Escherichia coli]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTAGATTTGCCGTTCATAGATTGAGCCTCA

Structures

Antitoxin