42268

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) symE-agrB/SymE(toxin)
Location 5470589..5471001 Replicon chromosome
Accession NZ_AP026108
Organism Escherichia coli strain CEC13091

Toxin (Protein)


Gene name symE Uniprot ID Q8FA88
Locus tag OO842_RS27220 Protein ID WP_000132630.1
Coordinates 5470589..5470930 (-) Length 114 a.a.

Antitoxin (RNA)


Gene name agrB
Locus tag -
Coordinates 5470925..5471001 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OO842_RS27200 (5466600) 5466600..5468012 - 1413 WP_000199295.1 PLP-dependent aminotransferase family protein -
OO842_RS27205 (5468189) 5468189..5468353 + 165 WP_000394274.1 DUF1127 domain-containing protein -
OO842_RS27210 (5468450) 5468450..5469331 + 882 WP_001304007.1 DUF262 domain-containing protein -
OO842_RS27215 (5469379) 5469379..5470542 + 1164 WP_001304006.1 DUF1524 domain-containing protein -
OO842_RS27220 (5470589) 5470589..5470930 - 342 WP_000132630.1 endoribonuclease SymE Toxin
- (5470925) 5470925..5471001 + 77 NuclAT_14 - Antitoxin
- (5470925) 5470925..5471001 + 77 NuclAT_14 - Antitoxin
- (5470925) 5470925..5471001 + 77 NuclAT_14 - Antitoxin
- (5470925) 5470925..5471001 + 77 NuclAT_14 - Antitoxin
- (5470925) 5470925..5471001 + 77 NuclAT_15 - Antitoxin
- (5470925) 5470925..5471001 + 77 NuclAT_15 - Antitoxin
- (5470925) 5470925..5471001 + 77 NuclAT_15 - Antitoxin
- (5470925) 5470925..5471001 + 77 NuclAT_15 - Antitoxin
OO842_RS27225 (5471151) 5471151..5472905 - 1755 WP_000110082.1 restriction endonuclease subunit S -
OO842_RS27230 (5472905) 5472905..5474374 - 1470 WP_001302468.1 type I restriction-modification system subunit M -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 5460107..5478802 18695


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(20-71)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12294.13 Da        Isoelectric Point: 8.4982

>T42268 WP_000132630.1 NZ_AP026108:c5470930-5470589 [Escherichia coli]
MTDTHSIAQPFEAEVSPANNRQLTVSYASRYPDYSRIPAITLKGQWLEAAGFATGTVVDVKVMEGCIVLTAQPPAAAESE
LMQSLRQVCKLSARKQRQVQEFIGVIAGKQKVA

Download         Length: 342 bp

>T42268 NZ_AP026108:c5470930-5470589 [Escherichia coli]
ATGACTGATACGCATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCCCCGGCAAATAACCGTCAATTAACCGTGAGTTA
TGCGAGTCGTTACCCGGATTACAGCCGTATTCCCGCCATCACCCTGAAAGGTCAGTGGCTGGAAGCCGCCGGTTTTGCCA
CCGGCACGGTGGTAGATGTCAAAGTGATGGAAGGCTGTATTGTCCTCACCGCCCAACCACCCGCCGCCGCCGAGAGCGAA
CTGATGCAGTCGCTGCGCCAGGTGTGCAAGCTGTCGGCGCGTAAACAAAGGCAGGTGCAGGAGTTTATTGGGGTGATTGC
GGGTAAACAGAAAGTTGCCTGA

Antitoxin


Download         Length: 77 bp

>AT42268 NZ_AP026108:5470925-5471001 [Escherichia coli]
AGTCATAACTGCTATTCCCTATAAATAGTGATTGTGATTAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y5T0

Antitoxin

Download structure file

References