Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1472051..1472846 Replicon chromosome
Accession NZ_AP026108
Organism Escherichia coli strain CEC13091

Toxin (Protein)


Gene name yeeV Uniprot ID B7UP43
Locus tag OO842_RS07025 Protein ID WP_000854914.1
Coordinates 1472472..1472846 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A0B0VS41
Locus tag OO842_RS07020 Protein ID WP_001280954.1
Coordinates 1472051..1472425 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OO842_RS06995 (1469513) 1469513..1469624 - 112 Protein_1372 hypothetical protein -
OO842_RS07000 (1469718) 1469718..1470536 + 819 WP_001234682.1 DUF932 domain-containing protein -
OO842_RS07005 (1470627) 1470627..1471112 + 486 WP_000214398.1 antirestriction protein -
OO842_RS07010 (1471128) 1471128..1471604 + 477 WP_001186738.1 RadC family protein -
OO842_RS07015 (1471667) 1471667..1471888 + 222 WP_001220314.1 DUF987 domain-containing protein -
OO842_RS07020 (1472051) 1472051..1472425 + 375 WP_001280954.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
OO842_RS07025 (1472472) 1472472..1472846 + 375 WP_000854914.1 TA system toxin CbtA family protein Toxin
OO842_RS07030 (1472843) 1472843..1473334 + 492 WP_000976853.1 DUF5983 family protein -
OO842_RS07035 (1473346) 1473346..1473543 + 198 WP_000839282.1 DUF957 domain-containing protein -
OO842_RS07040 (1473628) 1473628..1474188 + 561 Protein_1381 DUF4942 domain-containing protein -
OO842_RS07045 (1475535) 1475535..1475816 + 282 Protein_1382 DUF4942 domain-containing protein -
OO842_RS07055 (1476287) 1476287..1477225 + 939 WP_000351284.1 glyoxylate/hydroxypyruvate reductase GhrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - csgG / csgF / csgE / csgD / csgB / csgA / csgC 1472051..1484756 12705


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 14117.17 Da        Isoelectric Point: 7.7761

>T42242 WP_000854914.1 NZ_AP026108:1472472-1472846 [Escherichia coli]
MKTLSDTHVREVSRCPSPVTIWQTLLIRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T42242 NZ_AP026108:1472472-1472846 [Escherichia coli]
ATGAAAACATTATCCGACACACATGTACGGGAGGTATCTCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAT
CCGACTGCTGGACCAGCATTATGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCAGTTAATTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCACCTGTCCCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCTCGCCGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13718.51 Da        Isoelectric Point: 6.6249

>AT42242 WP_001280954.1 NZ_AP026108:1472051-1472425 [Escherichia coli]
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRYQHTVTLNAKGLTCEADTLGSCGYVYLAVYPTPAPATTS

Download         Length: 375 bp

>AT42242 NZ_AP026108:1472051-1472425 [Escherichia coli]
GTGTCAGACAAACTCTCCGGGATAACTCATCCCGATGACAATCACGACCGCCCCTGGTGGGGGCTTCCCTGCACAGTGAG
GCCCTGTTTTGGCGCTCGTCTGGTGCAAGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGCT
TCAGCGACGCAGATGCATACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGATATCAGCATACCGTCACGCTGAATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCAGCACCCGCAACCACCTCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LXR5

Antitoxin

Source ID Structure
AlphaFold DB A0A0B0VS41

References