Detailed information of TA system TA042240

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 1251704..1251929
• Replicon: chromosome
• Accession: NZ_AP026108
• Organism: Escherichia coli strain CEC13091

Toxin (Protein)

• Gene name: hokW
• Uniprot ID: -
• Locus tag: OO842_RS05875
• Protein ID: WP_000813263.1
• Coordinates: 1251774..1251929 (+)
• Length: 52 a.a.

Antitoxin (RNA)

Gene name	sokW
Locus tag	-
Coordinates	1251704..1251762 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
OO842_RS05845	1246979..1248070	+	1092	WP_001205823.1	hypothetical protein	-
OO842_RS05850	1248077..1248823	+	747	WP_000788745.1	ATP-binding protein	-
OO842_RS05855	1248845..1249615	+	771	WP_000450992.1	DUF1627 domain-containing protein	-
OO842_RS05860	1249631..1250044	+	414	WP_001151233.1	DUF977 family protein	-
OO842_RS05865	1250396..1251169	-	774	WP_000160654.1	alpha/beta hydrolase	-
-	1251704..1251762	-	59	-	-	Antitoxin
OO842_RS05875	1251774..1251929	+	156	WP_000813263.1	type I toxin-antitoxin system toxin HokD	Toxin
OO842_RS05880	1252097..1252375	+	279	WP_001341388.1	hypothetical protein	-
OO842_RS05885	1252377..1253426	+	1050	WP_001265172.1	DUF968 domain-containing protein	-
OO842_RS05890	1253439..1253810	+	372	WP_001217436.1	RusA family crossover junction endodeoxyribonuclease	-
OO842_RS05895	1253800..1254171	+	372	WP_000090264.1	antiterminator Q family protein	-
OO842_RS05900	1254323..1255141	+	819	WP_000265265.1	CPBP family intramembrane metalloprotease	-
OO842_RS05905	1255428..1255624	+	197	Protein_1158	TrmB family transcriptional regulator	-
OO842_RS05910	1255762..1256475	+	714	WP_000261909.1	helix-turn-helix domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 52 a.a.
• Molecular weight: 5722.86 Da
• Isoelectric Point: 6.1531

>T42240 WP_000813263.1 NZ_AP026108:1251774-1251929 [Escherichia coli]
MKQQKAMLIALIVICLTVIVTALVTRKDLCEVRVRTGQTEVAVFTAYEPEE

Nucleotide

• Length: 156 bp

>T42240 NZ_AP026108:1251774-1251929 [Escherichia coli]
ATGAAGCAGCAAAAGGCGATGTTAATCGCCCTGATCGTCATCTGTTTAACCGTCATAGTGACGGCACTGGTAACGAGGAA
AGACCTCTGCGAGGTACGAGTCCGAACCGGCCAGACGGAGGTCGCTGTCTTCACAGCTTACGAACCTGAGGAGTAA

Antitoxin

Nucleotide

• Length: 59 bp

>AT42240 NZ_AP026108:c1251762-1251704 [Escherichia coli]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTAGATTTGCCGTTCATAGATTGAGCCTCA

Structures

Antitoxin