Detailed information of TA system TA042201

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 1248655..1248880
• Replicon: chromosome
• Accession: NZ_AP026106
• Organism: Escherichia coli strain CEC01311

Toxin (Protein)

• Gene name: hokW
• Uniprot ID: -
• Locus tag: OO831_RS05865
• Protein ID: WP_000813263.1
• Coordinates: 1248725..1248880 (+)
• Length: 52 a.a.

Antitoxin (RNA)

Gene name	sokW
Locus tag	-
Coordinates	1248655..1248713 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
OO831_RS05835	1243930..1245021	+	1092	WP_001205823.1	hypothetical protein	-
OO831_RS05840	1245028..1245774	+	747	WP_000788745.1	ATP-binding protein	-
OO831_RS05845	1245796..1246566	+	771	WP_000450992.1	DUF1627 domain-containing protein	-
OO831_RS05850	1246582..1246995	+	414	WP_001151233.1	DUF977 family protein	-
OO831_RS05855	1247347..1248120	-	774	WP_000160654.1	alpha/beta hydrolase	-
-	1248655..1248713	-	59	-	-	Antitoxin
OO831_RS05865	1248725..1248880	+	156	WP_000813263.1	type I toxin-antitoxin system toxin HokD	Toxin
OO831_RS05870	1249048..1249326	+	279	WP_001341388.1	hypothetical protein	-
OO831_RS05875	1249328..1250377	+	1050	WP_001265172.1	DUF968 domain-containing protein	-
OO831_RS05880	1250390..1250761	+	372	WP_001217436.1	RusA family crossover junction endodeoxyribonuclease	-
OO831_RS05885	1250751..1251122	+	372	WP_000090264.1	antiterminator Q family protein	-
OO831_RS05890	1251274..1252092	+	819	WP_000265265.1	CPBP family intramembrane metalloprotease	-
OO831_RS05895	1252379..1252575	+	197	Protein_1156	TrmB family transcriptional regulator	-
OO831_RS05900	1252713..1253426	+	714	WP_000261909.1	helix-turn-helix domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 52 a.a.
• Molecular weight: 5722.86 Da
• Isoelectric Point: 6.1531

>T42201 WP_000813263.1 NZ_AP026106:1248725-1248880 [Escherichia coli]
MKQQKAMLIALIVICLTVIVTALVTRKDLCEVRVRTGQTEVAVFTAYEPEE

Nucleotide

• Length: 156 bp

>T42201 NZ_AP026106:1248725-1248880 [Escherichia coli]
ATGAAGCAGCAAAAGGCGATGTTAATCGCCCTGATCGTCATCTGTTTAACCGTCATAGTGACGGCACTGGTAACGAGGAA
AGACCTCTGCGAGGTACGAGTCCGAACCGGCCAGACGGAGGTCGCTGTCTTCACAGCTTACGAACCTGAGGAGTAA

Antitoxin

Nucleotide

• Length: 59 bp

>AT42201 NZ_AP026106:c1248713-1248655 [Escherichia coli]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTAGATTTGCCGTTCATAGATTGAGCCTCA

Structures

Antitoxin