42190

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) symE-agrB/SymE(toxin)
Location 5329518..5329930 Replicon chromosome
Accession NZ_AP026104
Organism Escherichia coli strain CEC96047

Toxin (Protein)


Gene name symE Uniprot ID Q8FA88
Locus tag OO843_RS26450 Protein ID WP_000132630.1
Coordinates 5329518..5329859 (-) Length 114 a.a.

Antitoxin (RNA)


Gene name agrB
Locus tag -
Coordinates 5329854..5329930 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OO843_RS27165 (5325086) 5325086..5325286 + 201 WP_001310455.1 hypothetical protein -
OO843_RS26430 (5325529) 5325529..5326941 - 1413 WP_000199295.1 PLP-dependent aminotransferase family protein -
OO843_RS26435 (5327118) 5327118..5327282 + 165 WP_000394274.1 DUF1127 domain-containing protein -
OO843_RS26440 (5327379) 5327379..5328260 + 882 WP_001304007.1 DUF262 domain-containing protein -
OO843_RS26445 (5328308) 5328308..5329471 + 1164 WP_001304006.1 DUF1524 domain-containing protein -
OO843_RS26450 (5329518) 5329518..5329859 - 342 WP_000132630.1 endoribonuclease SymE Toxin
- (5329854) 5329854..5329930 + 77 NuclAT_14 - Antitoxin
- (5329854) 5329854..5329930 + 77 NuclAT_14 - Antitoxin
- (5329854) 5329854..5329930 + 77 NuclAT_14 - Antitoxin
- (5329854) 5329854..5329930 + 77 NuclAT_14 - Antitoxin
- (5329854) 5329854..5329930 + 77 NuclAT_15 - Antitoxin
- (5329854) 5329854..5329930 + 77 NuclAT_15 - Antitoxin
- (5329854) 5329854..5329930 + 77 NuclAT_15 - Antitoxin
- (5329854) 5329854..5329930 + 77 NuclAT_15 - Antitoxin
OO843_RS26455 (5330080) 5330080..5331834 - 1755 WP_000110082.1 restriction endonuclease subunit S -
OO843_RS26460 (5331834) 5331834..5333303 - 1470 WP_001302468.1 type I restriction-modification system subunit M -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 5319011..5337731 18720


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(20-71)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12294.13 Da        Isoelectric Point: 8.4982

>T42190 WP_000132630.1 NZ_AP026104:c5329859-5329518 [Escherichia coli]
MTDTHSIAQPFEAEVSPANNRQLTVSYASRYPDYSRIPAITLKGQWLEAAGFATGTVVDVKVMEGCIVLTAQPPAAAESE
LMQSLRQVCKLSARKQRQVQEFIGVIAGKQKVA

Download         Length: 342 bp

>T42190 NZ_AP026104:c5329859-5329518 [Escherichia coli]
ATGACTGATACGCATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCCCCGGCAAATAACCGTCAATTAACCGTGAGTTA
TGCGAGTCGTTACCCGGATTACAGCCGTATTCCCGCCATCACCCTGAAAGGTCAGTGGCTGGAAGCCGCCGGTTTTGCCA
CCGGCACGGTGGTAGATGTCAAAGTGATGGAAGGCTGTATTGTCCTCACCGCCCAACCACCCGCCGCCGCCGAGAGCGAA
CTGATGCAGTCGCTGCGCCAGGTGTGCAAGCTGTCGGCGCGTAAACAAAGGCAGGTGCAGGAGTTTATTGGGGTGATTGC
GGGTAAACAGAAAGTTGCCTGA

Antitoxin


Download         Length: 77 bp

>AT42190 NZ_AP026104:5329854-5329930 [Escherichia coli]
AGTCATAACTGCTATTCCCTATAAATAGTGATTGTGATTAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y5T0

Antitoxin

Download structure file

References