Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 2263312..2264107 Replicon chromosome
Accession NZ_AP026104
Organism Escherichia coli strain CEC96047

Toxin (Protein)


Gene name yeeV Uniprot ID B7UP43
Locus tag OO843_RS11240 Protein ID WP_000854914.1
Coordinates 2263312..2263686 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A0B0VS41
Locus tag OO843_RS11245 Protein ID WP_001280954.1
Coordinates 2263733..2264107 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OO843_RS11200 (2258316) 2258316..2258807 - 492 WP_001301587.1 DUF1097 domain-containing protein -
OO843_RS11205 (2258909) 2258909..2259463 - 555 WP_001001917.1 molecular chaperone YcdY -
OO843_RS11210 (2259487) 2259487..2260224 - 738 WP_000283664.1 zinc-binding phosphatase -
OO843_RS11215 (2260279) 2260279..2261217 - 939 WP_000351284.1 glyoxylate/hydroxypyruvate reductase GhrA -
OO843_RS11225 (2261688) 2261688..2262530 - 843 WP_001280481.1 DUF4942 domain-containing protein -
OO843_RS11230 (2262615) 2262615..2262812 - 198 WP_000839282.1 DUF957 domain-containing protein -
OO843_RS11235 (2262824) 2262824..2263315 - 492 WP_000976853.1 DUF5983 family protein -
OO843_RS11240 (2263312) 2263312..2263686 - 375 WP_000854914.1 TA system toxin CbtA family protein Toxin
OO843_RS11245 (2263733) 2263733..2264107 - 375 WP_001280954.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
OO843_RS11250 (2264270) 2264270..2264491 - 222 WP_001220314.1 DUF987 domain-containing protein -
OO843_RS11255 (2264554) 2264554..2265030 - 477 WP_001186738.1 RadC family protein -
OO843_RS11260 (2265046) 2265046..2265531 - 486 WP_000214398.1 antirestriction protein -
OO843_RS11265 (2265622) 2265622..2266440 - 819 WP_001234682.1 DUF932 domain-containing protein -
OO843_RS11270 (2266780) 2266780..2267850 - 1071 WP_000102669.1 patatin-like phospholipase family protein -
OO843_RS11275 (2267847) 2267847..2268752 - 906 WP_000203541.1 diguanylate cyclase regulator RdcB family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - csgB / csgD / csgE / csgF / csgG 2254698..2265531 10833


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 14117.17 Da        Isoelectric Point: 7.7761

>T42178 WP_000854914.1 NZ_AP026104:c2263686-2263312 [Escherichia coli]
MKTLSDTHVREVSRCPSPVTIWQTLLIRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T42178 NZ_AP026104:c2263686-2263312 [Escherichia coli]
ATGAAAACATTATCCGACACACATGTACGGGAGGTATCTCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAT
CCGACTGCTGGACCAGCATTATGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCAGTTAATTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCACCTGTCCCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCTCGCCGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13718.51 Da        Isoelectric Point: 6.6249

>AT42178 WP_001280954.1 NZ_AP026104:c2264107-2263733 [Escherichia coli]
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRYQHTVTLNAKGLTCEADTLGSCGYVYLAVYPTPAPATTS

Download         Length: 375 bp

>AT42178 NZ_AP026104:c2264107-2263733 [Escherichia coli]
GTGTCAGACAAACTCTCCGGGATAACTCATCCCGATGACAATCACGACCGCCCCTGGTGGGGGCTTCCCTGCACAGTGAG
GCCCTGTTTTGGCGCTCGTCTGGTGCAAGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGCT
TCAGCGACGCAGATGCATACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGATATCAGCATACCGTCACGCTGAATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCAGCACCCGCAACCACCTCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LXR5

Antitoxin

Source ID Structure
AlphaFold DB A0A0B0VS41

References