Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) symE-agrB/SymE(toxin)
Location 5452849..5453261 Replicon chromosome
Accession NZ_AP026101
Organism Escherichia coli strain 93_161312

Toxin (Protein)


Gene name symE Uniprot ID Q8FA88
Locus tag OO868_RS27265 Protein ID WP_000132630.1
Coordinates 5452849..5453190 (-) Length 114 a.a.

Antitoxin (RNA)


Gene name agrB
Locus tag -
Coordinates 5453185..5453261 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OO868_RS28320 (5448417) 5448417..5448617 + 201 WP_001310455.1 hypothetical protein -
OO868_RS27245 (5448860) 5448860..5450272 - 1413 WP_000199295.1 PLP-dependent aminotransferase family protein -
OO868_RS27250 (5450449) 5450449..5450613 + 165 WP_000394274.1 DUF1127 domain-containing protein -
OO868_RS27255 (5450710) 5450710..5451591 + 882 WP_001304007.1 DUF262 domain-containing protein -
OO868_RS27260 (5451639) 5451639..5452802 + 1164 WP_001304006.1 DUF1524 domain-containing protein -
OO868_RS27265 (5452849) 5452849..5453190 - 342 WP_000132630.1 endoribonuclease SymE Toxin
- (5453185) 5453185..5453261 + 77 NuclAT_14 - Antitoxin
- (5453185) 5453185..5453261 + 77 NuclAT_14 - Antitoxin
- (5453185) 5453185..5453261 + 77 NuclAT_14 - Antitoxin
- (5453185) 5453185..5453261 + 77 NuclAT_14 - Antitoxin
- (5453185) 5453185..5453261 + 77 NuclAT_15 - Antitoxin
- (5453185) 5453185..5453261 + 77 NuclAT_15 - Antitoxin
- (5453185) 5453185..5453261 + 77 NuclAT_15 - Antitoxin
- (5453185) 5453185..5453261 + 77 NuclAT_15 - Antitoxin
OO868_RS27270 (5453411) 5453411..5455165 - 1755 WP_000110082.1 restriction endonuclease subunit S -
OO868_RS27275 (5455165) 5455165..5456634 - 1470 WP_001302468.1 type I restriction-modification system subunit M -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 5442342..5461062 18720


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(20-71)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12294.13 Da        Isoelectric Point: 8.4982

>T42156 WP_000132630.1 NZ_AP026101:c5453190-5452849 [Escherichia coli]
MTDTHSIAQPFEAEVSPANNRQLTVSYASRYPDYSRIPAITLKGQWLEAAGFATGTVVDVKVMEGCIVLTAQPPAAAESE
LMQSLRQVCKLSARKQRQVQEFIGVIAGKQKVA

Download         Length: 342 bp

>T42156 NZ_AP026101:c5453190-5452849 [Escherichia coli]
ATGACTGATACGCATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCCCCGGCAAATAACCGTCAATTAACCGTGAGTTA
TGCGAGTCGTTACCCGGATTACAGCCGTATTCCCGCCATCACCCTGAAAGGTCAGTGGCTGGAAGCCGCCGGTTTTGCCA
CCGGCACGGTGGTAGATGTCAAAGTGATGGAAGGCTGTATTGTCCTCACCGCCCAACCACCCGCCGCCGCCGAGAGCGAA
CTGATGCAGTCGCTGCGCCAGGTGTGCAAGCTGTCGGCGCGTAAACAAAGGCAGGTGCAGGAGTTTATTGGGGTGATTGC
GGGTAAACAGAAAGTTGCCTGA

Antitoxin


Download         Length: 77 bp

>AT42156 NZ_AP026101:5453185-5453261 [Escherichia coli]
AGTCATAACTGCTATTCCCTATAAATAGTGATTGTGATTAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y5T0

Antitoxin

Download structure file

References