Detailed information of TA system TA042141

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 1703075..1703300
• Replicon: chromosome
• Accession: NZ_AP026101
• Organism: Escherichia coli strain 93_161312

Toxin (Protein)

• Gene name: hokW
• Uniprot ID: A0A1Q4PF16
• Locus tag: OO868_RS08375
• Protein ID: WP_000813258.1
• Coordinates: 1703145..1703300 (+)
• Length: 52 a.a.

Antitoxin (RNA)

Gene name	sokW
Locus tag	-
Coordinates	1703075..1703133 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
OO868_RS08325	1698140..1698382	+	243	WP_000747948.1	Cro/CI family transcriptional regulator	-
OO868_RS08330	1698366..1698791	+	426	WP_000693878.1	toxin YdaT family protein	-
OO868_RS08335	1698860..1699903	+	1044	WP_001262402.1	DnaT-like ssDNA-binding domain-containing protein	-
OO868_RS08340	1699896..1700357	+	462	WP_000139447.1	replication protein P	-
OO868_RS08345	1700391..1701107	+	717	WP_000450627.1	DUF1627 domain-containing protein	-
OO868_RS08350	1701140..1701421	+	282	WP_000603384.1	DNA-binding protein	-
OO868_RS08355	1701418..1701645	+	228	WP_000699809.1	hypothetical protein	-
OO868_RS08360	1701638..1701949	+	312	WP_001289673.1	hypothetical protein	-
OO868_RS08365	1702077..1702295	+	219	WP_000683609.1	DUF4014 family protein	-
OO868_RS08370	1702297..1702854	+	558	WP_000104474.1	DUF551 domain-containing protein	-
-	1703075..1703133	-	59	-	-	Antitoxin
OO868_RS08375	1703145..1703300	+	156	WP_000813258.1	Hok/Gef family protein	Toxin
OO868_RS08380	1703420..1703764	+	345	WP_000756596.1	YgiW/YdeI family stress tolerance OB fold protein	-
OO868_RS08385	1703886..1704158	+	273	WP_000191870.1	hypothetical protein	-
OO868_RS08390	1704160..1705209	+	1050	WP_001265229.1	DUF968 domain-containing protein	-
OO868_RS08395	1705222..1705527	+	306	WP_001217444.1	RusA family crossover junction endodeoxyribonuclease	-
OO868_RS08400	1705590..1706144	+	555	WP_000640035.1	DUF1133 family protein	-
OO868_RS08405	1706369..1706566	+	198	WP_000917763.1	hypothetical protein	-
OO868_RS08410	1706702..1707415	+	714	WP_000301797.1	helix-turn-helix domain-containing protein	-
OO868_RS08425	1707870..1708298	+	429	WP_001303509.1	tellurite resistance protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	nleG7'	1641096..1740758	99662

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 52 a.a.
• Molecular weight: 5767.95 Da
• Isoelectric Point: 7.7942

>T42141 WP_000813258.1 NZ_AP026101:1703145-1703300 [Escherichia coli]
MKQQKAMLIALIVICLTVIVTALVTRKDLCEVRIRTGQTEVAVFVDYESEK

Nucleotide

• Length: 156 bp

>T42141 NZ_AP026101:1703145-1703300 [Escherichia coli]
ATGAAGCAGCAAAAGGCGATGTTAATCGCCCTGATCGTCATCTGTTTAACCGTCATAGTGACGGCACTGGTAACGAGGAA
AGACCTCTGCGAGGTGCGAATCCGAACCGGTCAGACGGAGGTCGCTGTCTTCGTAGACTACGAATCTGAGAAGTAA

Antitoxin

Nucleotide

• Length: 59 bp

>AT42141 NZ_AP026101:c1703133-1703075 [Escherichia coli]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACATGTGTTCAGCATGGATTGAGCCTCA

Structures

Toxin

• AlphaFold DB: A0A1Q4PF16

Antitoxin