Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type I Classification (family/domain) hok-sok/-
Location 1180497..1180722 Replicon chromosome
Accession NZ_AP026101
Organism Escherichia coli strain 93_161312

Toxin (Protein)


Gene name hokW Uniprot ID -
Locus tag OO868_RS05480 Protein ID WP_000813263.1
Coordinates 1180567..1180722 (+) Length 52 a.a.

Antitoxin (RNA)


Gene name sokW
Locus tag -
Coordinates 1180497..1180555 (-)

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OO868_RS05450 1175772..1176863 + 1092 WP_001205823.1 hypothetical protein -
OO868_RS05455 1176870..1177616 + 747 WP_000788745.1 ATP-binding protein -
OO868_RS05460 1177638..1178408 + 771 WP_000450992.1 DUF1627 domain-containing protein -
OO868_RS05465 1178424..1178837 + 414 WP_001151233.1 DUF977 family protein -
OO868_RS05470 1179189..1179962 - 774 WP_000160654.1 alpha/beta hydrolase -
- 1180497..1180555 - 59 - - Antitoxin
OO868_RS05480 1180567..1180722 + 156 WP_000813263.1 type I toxin-antitoxin system toxin HokD Toxin
OO868_RS05485 1180890..1181168 + 279 WP_001341388.1 hypothetical protein -
OO868_RS05490 1181170..1182219 + 1050 WP_001265172.1 DUF968 domain-containing protein -
OO868_RS05495 1182232..1182603 + 372 WP_001217436.1 RusA family crossover junction endodeoxyribonuclease -
OO868_RS05500 1182593..1182964 + 372 WP_000090264.1 antiterminator Q family protein -
OO868_RS05505 1183116..1183934 + 819 WP_000265265.1 CPBP family intramembrane metalloprotease -
OO868_RS05510 1184221..1184417 + 197 Protein_1079 TrmB family transcriptional regulator -
OO868_RS05515 1184555..1185268 + 714 WP_000261909.1 helix-turn-helix domain-containing protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(6-47)


Sequences


Toxin        


Download         Length: 52 a.a.        Molecular weight: 5722.86 Da        Isoelectric Point: 6.1531

>T42130 WP_000813263.1 NZ_AP026101:1180567-1180722 [Escherichia coli]
MKQQKAMLIALIVICLTVIVTALVTRKDLCEVRVRTGQTEVAVFTAYEPEE

Download         Length: 156 bp

>T42130 NZ_AP026101:1180567-1180722 [Escherichia coli]
ATGAAGCAGCAAAAGGCGATGTTAATCGCCCTGATCGTCATCTGTTTAACCGTCATAGTGACGGCACTGGTAACGAGGAA
AGACCTCTGCGAGGTACGAGTCCGAACCGGCCAGACGGAGGTCGCTGTCTTCACAGCTTACGAACCTGAGGAGTAA

Antitoxin


Download         Length: 59 bp

>AT42130 NZ_AP026101:c1180555-1180497 [Escherichia coli]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTAGATTTGCCGTTCATAGATTGAGCCTCA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Download structure file

References