42101

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1448114..1448909 Replicon chromosome
Accession NZ_AP026099
Organism Escherichia coli strain 61_150228

Toxin (Protein)


Gene name yeeV Uniprot ID B7UP43
Locus tag OO862_RS06995 Protein ID WP_000854914.1
Coordinates 1448535..1448909 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A0B0VS41
Locus tag OO862_RS06990 Protein ID WP_001280954.1
Coordinates 1448114..1448488 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OO862_RS06960 (1443469) 1443469..1444374 + 906 WP_000203541.1 diguanylate cyclase regulator RdcB family protein -
OO862_RS06965 (1444371) 1444371..1445441 + 1071 WP_000102669.1 patatin-like phospholipase family protein -
OO862_RS06970 (1445781) 1445781..1446599 + 819 WP_001234682.1 DUF932 domain-containing protein -
OO862_RS06975 (1446690) 1446690..1447175 + 486 WP_000214398.1 antirestriction protein -
OO862_RS06980 (1447191) 1447191..1447667 + 477 WP_001186738.1 RadC family protein -
OO862_RS06985 (1447730) 1447730..1447951 + 222 WP_001220314.1 DUF987 domain-containing protein -
OO862_RS06990 (1448114) 1448114..1448488 + 375 WP_001280954.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
OO862_RS06995 (1448535) 1448535..1448909 + 375 WP_000854914.1 TA system toxin CbtA family protein Toxin
OO862_RS07000 (1448906) 1448906..1449397 + 492 WP_000976853.1 DUF5983 family protein -
OO862_RS07005 (1449409) 1449409..1449606 + 198 WP_000839282.1 DUF957 domain-containing protein -
OO862_RS07010 (1449691) 1449691..1450533 + 843 WP_001280481.1 DUF4942 domain-containing protein -
OO862_RS07020 (1451004) 1451004..1451942 + 939 WP_000351284.1 glyoxylate/hydroxypyruvate reductase GhrA -
OO862_RS07025 (1451997) 1451997..1452734 + 738 WP_000283664.1 zinc-binding phosphatase -
OO862_RS07030 (1452758) 1452758..1453312 + 555 WP_001001917.1 molecular chaperone YcdY -
OO862_RS07035 (1453414) 1453414..1453905 + 492 WP_001301587.1 DUF1097 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - csgG / csgF / csgE / csgD / csgB / csgA / csgC 1447191..1459473 12282


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 14117.17 Da        Isoelectric Point: 7.7761

>T42101 WP_000854914.1 NZ_AP026099:1448535-1448909 [Escherichia coli]
MKTLSDTHVREVSRCPSPVTIWQTLLIRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T42101 NZ_AP026099:1448535-1448909 [Escherichia coli]
ATGAAAACATTATCCGACACACATGTACGGGAGGTATCTCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAT
CCGACTGCTGGACCAGCATTATGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCAGTTAATTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCACCTGTCCCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCTCGCCGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13718.51 Da        Isoelectric Point: 6.6249

>AT42101 WP_001280954.1 NZ_AP026099:1448114-1448488 [Escherichia coli]
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRYQHTVTLNAKGLTCEADTLGSCGYVYLAVYPTPAPATTS

Download         Length: 375 bp

>AT42101 NZ_AP026099:1448114-1448488 [Escherichia coli]
GTGTCAGACAAACTCTCCGGGATAACTCATCCCGATGACAATCACGACCGCCCCTGGTGGGGGCTTCCCTGCACAGTGAG
GCCCTGTTTTGGCGCTCGTCTGGTGCAAGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGCT
TCAGCGACGCAGATGCATACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGATATCAGCATACCGTCACGCTGAATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCAGCACCCGCAACCACCTCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LXR5

Antitoxin

Source ID Structure
AlphaFold DB A0A0B0VS41

References