42055

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) symE-agrB/SymE(toxin)
Location 5325362..5325774 Replicon chromosome
Accession NZ_AP026095
Organism Escherichia coli strain 53_142304

Toxin (Protein)


Gene name symE Uniprot ID Q8FA88
Locus tag OO816_RS26430 Protein ID WP_000132630.1
Coordinates 5325362..5325703 (-) Length 114 a.a.

Antitoxin (RNA)


Gene name agrB
Locus tag -
Coordinates 5325698..5325774 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OO816_RS27300 (5320930) 5320930..5321130 + 201 WP_001310455.1 hypothetical protein -
OO816_RS26410 (5321373) 5321373..5322785 - 1413 WP_000199295.1 PLP-dependent aminotransferase family protein -
OO816_RS26415 (5322962) 5322962..5323126 + 165 WP_000394274.1 DUF1127 domain-containing protein -
OO816_RS26420 (5323223) 5323223..5324104 + 882 WP_001304007.1 DUF262 domain-containing protein -
OO816_RS26425 (5324152) 5324152..5325315 + 1164 WP_001304006.1 DUF1524 domain-containing protein -
OO816_RS26430 (5325362) 5325362..5325703 - 342 WP_000132630.1 endoribonuclease SymE Toxin
- (5325698) 5325698..5325774 + 77 NuclAT_14 - Antitoxin
- (5325698) 5325698..5325774 + 77 NuclAT_14 - Antitoxin
- (5325698) 5325698..5325774 + 77 NuclAT_14 - Antitoxin
- (5325698) 5325698..5325774 + 77 NuclAT_14 - Antitoxin
- (5325698) 5325698..5325774 + 77 NuclAT_15 - Antitoxin
- (5325698) 5325698..5325774 + 77 NuclAT_15 - Antitoxin
- (5325698) 5325698..5325774 + 77 NuclAT_15 - Antitoxin
- (5325698) 5325698..5325774 + 77 NuclAT_15 - Antitoxin
OO816_RS26435 (5325924) 5325924..5327678 - 1755 WP_000110082.1 restriction endonuclease subunit S -
OO816_RS26440 (5327678) 5327678..5329147 - 1470 WP_001302468.1 type I restriction-modification system subunit M -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 5314855..5333575 18720


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(20-71)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12294.13 Da        Isoelectric Point: 8.4982

>T42055 WP_000132630.1 NZ_AP026095:c5325703-5325362 [Escherichia coli]
MTDTHSIAQPFEAEVSPANNRQLTVSYASRYPDYSRIPAITLKGQWLEAAGFATGTVVDVKVMEGCIVLTAQPPAAAESE
LMQSLRQVCKLSARKQRQVQEFIGVIAGKQKVA

Download         Length: 342 bp

>T42055 NZ_AP026095:c5325703-5325362 [Escherichia coli]
ATGACTGATACGCATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCCCCGGCAAATAACCGTCAATTAACCGTGAGTTA
TGCGAGTCGTTACCCGGATTACAGCCGTATTCCCGCCATCACCCTGAAAGGTCAGTGGCTGGAAGCCGCCGGTTTTGCCA
CCGGCACGGTGGTAGATGTCAAAGTGATGGAAGGCTGTATTGTCCTCACCGCCCAACCACCCGCCGCCGCCGAGAGCGAA
CTGATGCAGTCGCTGCGCCAGGTGTGCAAGCTGTCGGCGCGTAAACAAAGGCAGGTGCAGGAGTTTATTGGGGTGATTGC
GGGTAAACAGAAAGTTGCCTGA

Antitoxin


Download         Length: 77 bp

>AT42055 NZ_AP026095:5325698-5325774 [Escherichia coli]
AGTCATAACTGCTATTCCCTATAAATAGTGATTGTGATTAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y5T0

Antitoxin

Download structure file

References