Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3214200..3214995 Replicon chromosome
Accession NZ_AP026095
Organism Escherichia coli strain 53_142304

Toxin (Protein)


Gene name yeeV Uniprot ID B7UP43
Locus tag OO816_RS16370 Protein ID WP_000854914.1
Coordinates 3214200..3214574 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A0B0VS41
Locus tag OO816_RS16375 Protein ID WP_001280954.1
Coordinates 3214621..3214995 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OO816_RS16330 (3209204) 3209204..3209695 - 492 WP_001301587.1 DUF1097 domain-containing protein -
OO816_RS16335 (3209797) 3209797..3210351 - 555 WP_264831385.1 molecular chaperone YcdY -
OO816_RS16340 (3210375) 3210375..3211112 - 738 WP_000283664.1 zinc-binding phosphatase -
OO816_RS16345 (3211167) 3211167..3212105 - 939 WP_000351284.1 glyoxylate/hydroxypyruvate reductase GhrA -
OO816_RS16355 (3212576) 3212576..3213418 - 843 WP_001280481.1 DUF4942 domain-containing protein -
OO816_RS16360 (3213503) 3213503..3213700 - 198 WP_000839282.1 DUF957 domain-containing protein -
OO816_RS16365 (3213712) 3213712..3214203 - 492 WP_000976853.1 DUF5983 family protein -
OO816_RS16370 (3214200) 3214200..3214574 - 375 WP_000854914.1 TA system toxin CbtA family protein Toxin
OO816_RS16375 (3214621) 3214621..3214995 - 375 WP_001280954.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
OO816_RS16380 (3215158) 3215158..3215379 - 222 WP_001220314.1 DUF987 domain-containing protein -
OO816_RS16385 (3215442) 3215442..3215918 - 477 WP_001186738.1 RadC family protein -
OO816_RS16390 (3215934) 3215934..3216419 - 486 WP_000214398.1 antirestriction protein -
OO816_RS16395 (3216510) 3216510..3217328 - 819 WP_001234682.1 DUF932 domain-containing protein -
OO816_RS16400 (3217668) 3217668..3218738 - 1071 WP_000102669.1 patatin-like phospholipase family protein -
OO816_RS16405 (3218735) 3218735..3219640 - 906 WP_000203541.1 diguanylate cyclase regulator RdcB family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - csgB / csgD / csgE / csgF / csgG 3205586..3216419 10833


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 14117.17 Da        Isoelectric Point: 7.7761

>T42045 WP_000854914.1 NZ_AP026095:c3214574-3214200 [Escherichia coli]
MKTLSDTHVREVSRCPSPVTIWQTLLIRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T42045 NZ_AP026095:c3214574-3214200 [Escherichia coli]
ATGAAAACATTATCCGACACACATGTACGGGAGGTATCTCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAT
CCGACTGCTGGACCAGCATTATGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCAGTTAATTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCACCTGTCCCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCTCGCCGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13718.51 Da        Isoelectric Point: 6.6249

>AT42045 WP_001280954.1 NZ_AP026095:c3214995-3214621 [Escherichia coli]
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRYQHTVTLNAKGLTCEADTLGSCGYVYLAVYPTPAPATTS

Download         Length: 375 bp

>AT42045 NZ_AP026095:c3214995-3214621 [Escherichia coli]
GTGTCAGACAAACTCTCCGGGATAACTCATCCCGATGACAATCACGACCGCCCCTGGTGGGGGCTTCCCTGCACAGTGAG
GCCCTGTTTTGGCGCTCGTCTGGTGCAAGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGCT
TCAGCGACGCAGATGCATACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGATATCAGCATACCGTCACGCTGAATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCAGCACCCGCAACCACCTCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LXR5

Antitoxin

Source ID Structure
AlphaFold DB A0A0B0VS41

References