42018

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) symE-istR/SymE(toxin)
Location 5363270..5363682 Replicon chromosome
Accession NZ_AP026092
Organism Escherichia coli strain 27_141091

Toxin (Protein)


Gene name symE Uniprot ID Q8FA88
Locus tag OO959_RS26605 Protein ID WP_000132630.1
Coordinates 5363270..5363611 (-) Length 114 a.a.

Antitoxin (RNA)


Gene name istR
Locus tag -
Coordinates 5363606..5363682 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OO959_RS27900 (5358838) 5358838..5359038 + 201 WP_001310455.1 hypothetical protein -
OO959_RS26585 (5359281) 5359281..5360693 - 1413 WP_000199295.1 PLP-dependent aminotransferase family protein -
OO959_RS26590 (5360870) 5360870..5361034 + 165 WP_000394274.1 DUF1127 domain-containing protein -
OO959_RS26595 (5361131) 5361131..5362012 + 882 WP_001304007.1 DUF262 domain-containing protein -
OO959_RS26600 (5362060) 5362060..5363223 + 1164 WP_001304006.1 DUF1524 domain-containing protein -
OO959_RS26605 (5363270) 5363270..5363611 - 342 WP_000132630.1 endoribonuclease SymE Toxin
- (5363606) 5363606..5363682 + 77 NuclAT_15 - Antitoxin
- (5363606) 5363606..5363682 + 77 NuclAT_15 - Antitoxin
- (5363606) 5363606..5363682 + 77 NuclAT_15 - Antitoxin
- (5363606) 5363606..5363682 + 77 NuclAT_15 - Antitoxin
- (5363606) 5363606..5363682 + 77 NuclAT_16 - Antitoxin
- (5363606) 5363606..5363682 + 77 NuclAT_16 - Antitoxin
- (5363606) 5363606..5363682 + 77 NuclAT_16 - Antitoxin
- (5363606) 5363606..5363682 + 77 NuclAT_16 - Antitoxin
OO959_RS26610 (5363832) 5363832..5365586 - 1755 WP_000110082.1 restriction endonuclease subunit S -
OO959_RS26615 (5365586) 5365586..5367055 - 1470 WP_001302468.1 type I restriction-modification system subunit M -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 5352763..5371483 18720


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(20-71)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12294.13 Da        Isoelectric Point: 8.4982

>T42018 WP_000132630.1 NZ_AP026092:c5363611-5363270 [Escherichia coli]
MTDTHSIAQPFEAEVSPANNRQLTVSYASRYPDYSRIPAITLKGQWLEAAGFATGTVVDVKVMEGCIVLTAQPPAAAESE
LMQSLRQVCKLSARKQRQVQEFIGVIAGKQKVA

Download         Length: 342 bp

>T42018 NZ_AP026092:c5363611-5363270 [Escherichia coli]
ATGACTGATACGCATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCCCCGGCAAATAACCGTCAATTAACCGTGAGTTA
TGCGAGTCGTTACCCGGATTACAGCCGTATTCCCGCCATCACCCTGAAAGGTCAGTGGCTGGAAGCCGCCGGTTTTGCCA
CCGGCACGGTGGTAGATGTCAAAGTGATGGAAGGCTGTATTGTCCTCACCGCCCAACCACCCGCCGCCGCCGAGAGCGAA
CTGATGCAGTCGCTGCGCCAGGTGTGCAAGCTGTCGGCGCGTAAACAAAGGCAGGTGCAGGAGTTTATTGGGGTGATTGC
GGGTAAACAGAAAGTTGCCTGA

Antitoxin


Download         Length: 77 bp

>AT42018 NZ_AP026092:5363606-5363682 [Escherichia coli]
AGTCATAACTGCTATTCCCTATAAATAGTGATTGTGATTAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y5T0

Antitoxin

Download structure file

References