Detailed information of TA system TA042000

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ralRA/-
• Location: 1339006..1339377
• Replicon: chromosome
• Accession: NZ_AP026092
• Organism: Escherichia coli strain 27_141091

Toxin (Protein)

• Gene name: ralR
• Uniprot ID: A0A891STD1
• Locus tag: OO959_RS06395
• Protein ID: WP_042853000.1
• Coordinates: 1339183..1339377 (-)
• Length: 65 a.a.

Antitoxin (RNA)

Gene name	ralA
Locus tag	-
Coordinates	1339006..1339184 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
OO959_RS06355 (1334448)	1334448..1335104	-	657	WP_000011656.1	carbon-nitrogen hydrolase family protein YobB	-
OO959_RS06360 (1335206)	1335206..1335436	-	231	WP_000916763.1	DNA polymerase III subunit theta	-
OO959_RS06365 (1335575)	1335575..1335949	+	375	WP_000168751.1	CopC domain-containing protein YobA	-
OO959_RS06370 (1335953)	1335953..1336825	+	873	WP_000879314.1	copper homeostasis membrane protein CopD	-
OO959_RS06375 (1336838)	1336838..1337179	+	342	WP_000976483.1	YebY family protein	-
OO959_RS06380 (1337572)	1337572..1338648	-	1077	WP_045893699.1	phage integrase Arm DNA-binding domain-containing protein	-
OO959_RS06385 (1338614)	1338614..1338895	-	282	WP_001311878.1	excisionase	-
- (1339006)	1339006..1339184	+	179	NuclAT_0	-	Antitoxin
- (1339006)	1339006..1339184	+	179	NuclAT_0	-	Antitoxin
- (1339006)	1339006..1339184	+	179	NuclAT_0	-	Antitoxin
- (1339006)	1339006..1339184	+	179	NuclAT_0	-	Antitoxin
OO959_RS06390 (1339002)	1339002..1339190	-	189	WP_001356607.1	DUF1187 family protein	-
OO959_RS06395 (1339183)	1339183..1339377	-	195	WP_042853000.1	type I toxin-antitoxin system endodeoxyribonuclease toxin RalR	Toxin
OO959_RS06400 (1339434)	1339434..1340243	-	810	WP_000166313.1	recombination protein RecT	-
OO959_RS06405 (1340236)	1340236..1342905	-	2670	WP_000102194.1	exodeoxyribonuclease VIII	-
OO959_RS06410 (1342986)	1342986..1343156	-	171	WP_001427414.1	YdaE family protein	-
OO959_RS06415 (1343156)	1343156..1343377	-	222	WP_000560228.1	killing protein KilR	-
OO959_RS06420 (1343424)	1343424..1344275	-	852	WP_062882198.1	Rha family phage regulatory protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1331705..1398687	66982

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Endodeoxyribonuclease toxin RalR (6-54)

Sequences

Toxin

Protein

• Length: 65 a.a.
• Molecular weight: 7019.87 Da
• Isoelectric Point: 8.6419

>T42000 WP_042853000.1 NZ_AP026092:c1339377-1339183 [Escherichia coli]
MRYDDVKPCPFCGCPSVTVKAISGYYRAKCNGCESRTGYGGSEKEALERWNKRTTGNNNGGVHV

Nucleotide

• Length: 195 bp

>T42000 NZ_AP026092:c1339377-1339183 [Escherichia coli]
ATGAGATATGACGATGTTAAACCATGTCCGTTTTGTGGTTGTCCATCTGTTACAGTGAAAGCAATTTCAGGATATTACCG
GGCAAAATGCAACGGATGCGAATCCCGAACTGGCTATGGTGGAAGTGAAAAAGAAGCACTCGAAAGATGGAATAAACGAA
CTACTGGAAATAATAATGGAGGTGTTCATGTATAA

Antitoxin

Nucleotide

• Length: 179 bp

>AT42000 NZ_AP026092:1339006-1339184 [Escherichia coli]
GAGGACAGAAGTTTCTCGCAATTAAAATTTATCAGCTTTACTTTCTGCTCTCTGGACACGCCTGCTTCTTTTTTCCCTGA
GAGCATTTTTTCGCATTCTGATTTCGTTAATTTAGATTTTGAATATCTTGTCCAGTTAGTAGGAGTGCCACCTTCTTTTT
CAATAGTGGCAGTTATTTT

Structures

Antitoxin