41982

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) symE-agrB/SymE(toxin)
Location 5369404..5369816 Replicon chromosome
Accession NZ_AP026090
Organism Escherichia coli strain 26_141088

Toxin (Protein)


Gene name symE Uniprot ID Q8FA88
Locus tag OO788_RS26740 Protein ID WP_000132630.1
Coordinates 5369404..5369745 (-) Length 114 a.a.

Antitoxin (RNA)


Gene name agrB
Locus tag -
Coordinates 5369740..5369816 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OO788_RS27630 (5364972) 5364972..5365172 + 201 WP_001310455.1 hypothetical protein -
OO788_RS26720 (5365415) 5365415..5366827 - 1413 WP_000199295.1 PLP-dependent aminotransferase family protein -
OO788_RS26725 (5367004) 5367004..5367168 + 165 WP_000394274.1 DUF1127 domain-containing protein -
OO788_RS26730 (5367265) 5367265..5368146 + 882 WP_001304007.1 DUF262 domain-containing protein -
OO788_RS26735 (5368194) 5368194..5369357 + 1164 WP_001304006.1 DUF1524 domain-containing protein -
OO788_RS26740 (5369404) 5369404..5369745 - 342 WP_000132630.1 endoribonuclease SymE Toxin
- (5369740) 5369740..5369816 + 77 NuclAT_14 - Antitoxin
- (5369740) 5369740..5369816 + 77 NuclAT_14 - Antitoxin
- (5369740) 5369740..5369816 + 77 NuclAT_14 - Antitoxin
- (5369740) 5369740..5369816 + 77 NuclAT_14 - Antitoxin
- (5369740) 5369740..5369816 + 77 NuclAT_15 - Antitoxin
- (5369740) 5369740..5369816 + 77 NuclAT_15 - Antitoxin
- (5369740) 5369740..5369816 + 77 NuclAT_15 - Antitoxin
- (5369740) 5369740..5369816 + 77 NuclAT_15 - Antitoxin
OO788_RS26745 (5369966) 5369966..5371720 - 1755 WP_000110082.1 restriction endonuclease subunit S -
OO788_RS26750 (5371720) 5371720..5373189 - 1470 WP_001302468.1 type I restriction-modification system subunit M -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 5358897..5377617 18720


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(20-71)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12294.13 Da        Isoelectric Point: 8.4982

>T41982 WP_000132630.1 NZ_AP026090:c5369745-5369404 [Escherichia coli]
MTDTHSIAQPFEAEVSPANNRQLTVSYASRYPDYSRIPAITLKGQWLEAAGFATGTVVDVKVMEGCIVLTAQPPAAAESE
LMQSLRQVCKLSARKQRQVQEFIGVIAGKQKVA

Download         Length: 342 bp

>T41982 NZ_AP026090:c5369745-5369404 [Escherichia coli]
ATGACTGATACGCATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCCCCGGCAAATAACCGTCAATTAACCGTGAGTTA
TGCGAGTCGTTACCCGGATTACAGCCGTATTCCCGCCATCACCCTGAAAGGTCAGTGGCTGGAAGCCGCCGGTTTTGCCA
CCGGCACGGTGGTAGATGTCAAAGTGATGGAAGGCTGTATTGTCCTCACCGCCCAACCACCCGCCGCCGCCGAGAGCGAA
CTGATGCAGTCGCTGCGCCAGGTGTGCAAGCTGTCGGCGCGTAAACAAAGGCAGGTGCAGGAGTTTATTGGGGTGATTGC
GGGTAAACAGAAAGTTGCCTGA

Antitoxin


Download         Length: 77 bp

>AT41982 NZ_AP026090:5369740-5369816 [Escherichia coli]
AGTCATAACTGCTATTCCCTATAAATAGTGATTGTGATTAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y5T0

Antitoxin

Download structure file

References