Detailed information of TA system TA041960

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 2052884..2053109
• Replicon: chromosome
• Accession: NZ_AP026090
• Organism: Escherichia coli strain 26_141088

Toxin (Protein)

• Gene name: hokW
• Uniprot ID: A0A1Q4PF16
• Locus tag: OO788_RS10155
• Protein ID: WP_000813258.1
• Coordinates: 2052884..2053039 (-)
• Length: 52 a.a.

Antitoxin (RNA)

Gene name	sokW
Locus tag	-
Coordinates	2053051..2053109 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
OO788_RS10105	2047887..2048318	-	432	WP_001302123.1	tellurite resistance protein	-
OO788_RS10120	2048769..2049482	-	714	WP_000301797.1	helix-turn-helix domain-containing protein	-
OO788_RS10125	2049618..2049815	-	198	WP_000917763.1	hypothetical protein	-
OO788_RS10130	2050040..2050594	-	555	WP_000640035.1	DUF1133 family protein	-
OO788_RS10135	2050657..2050962	-	306	WP_001217444.1	RusA family crossover junction endodeoxyribonuclease	-
OO788_RS10140	2050975..2052024	-	1050	WP_001265229.1	DUF968 domain-containing protein	-
OO788_RS10145	2052026..2052298	-	273	WP_000191872.1	hypothetical protein	-
OO788_RS10150	2052420..2052764	-	345	WP_000756596.1	YgiW/YdeI family stress tolerance OB fold protein	-
OO788_RS10155	2052884..2053039	-	156	WP_000813258.1	Hok/Gef family protein	Toxin
-	2053051..2053109	+	59	-	-	Antitoxin
OO788_RS10160	2053330..2053887	-	558	WP_000104474.1	DUF551 domain-containing protein	-
OO788_RS10165	2053889..2054107	-	219	WP_000683609.1	DUF4014 family protein	-
OO788_RS10170	2054235..2054546	-	312	WP_001289673.1	hypothetical protein	-
OO788_RS10175	2054539..2054766	-	228	WP_000699809.1	hypothetical protein	-
OO788_RS10180	2054763..2055044	-	282	WP_000603384.1	DNA-binding protein	-
OO788_RS10185	2055077..2055793	-	717	WP_000450627.1	DUF1627 domain-containing protein	-
OO788_RS10190	2055827..2056288	-	462	WP_000139447.1	replication protein P	-
OO788_RS10195	2056281..2057324	-	1044	WP_001262402.1	DnaT-like ssDNA-binding domain-containing protein	-
OO788_RS10200	2057393..2057818	-	426	WP_000693878.1	toxin YdaT family protein	-
OO788_RS10205	2057802..2058044	-	243	WP_000747948.1	Cro/CI family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	nleG7'	2022429..2124123	101694

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 52 a.a.
• Molecular weight: 5767.95 Da
• Isoelectric Point: 7.7942

>T41960 WP_000813258.1 NZ_AP026090:c2053039-2052884 [Escherichia coli]
MKQQKAMLIALIVICLTVIVTALVTRKDLCEVRIRTGQTEVAVFVDYESEK

Nucleotide

• Length: 156 bp

>T41960 NZ_AP026090:c2053039-2052884 [Escherichia coli]
ATGAAGCAGCAAAAGGCGATGTTAATCGCCCTGATCGTCATCTGTTTAACCGTCATAGTGACGGCACTGGTAACGAGGAA
AGACCTCTGCGAGGTGCGAATCCGAACCGGTCAGACGGAGGTCGCTGTCTTCGTAGACTACGAATCTGAGAAGTAA

Antitoxin

Nucleotide

• Length: 59 bp

>AT41960 NZ_AP026090:2053051-2053109 [Escherichia coli]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACATGTGTTCAGCATGGATTGAGCCTCA

Structures

Toxin

• AlphaFold DB: A0A1Q4PF16

Antitoxin