Detailed information of TA system TA041954

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 1176963..1177188
• Replicon: chromosome
• Accession: NZ_AP026090
• Organism: Escherichia coli strain 26_141088

Toxin (Protein)

• Gene name: hokW
• Uniprot ID: -
• Locus tag: OO788_RS05460
• Protein ID: WP_000813263.1
• Coordinates: 1177033..1177188 (+)
• Length: 52 a.a.

Antitoxin (RNA)

Gene name	sokW
Locus tag	-
Coordinates	1176963..1177021 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
OO788_RS05430	1172238..1173329	+	1092	WP_001205823.1	hypothetical protein	-
OO788_RS05435	1173336..1174082	+	747	WP_000788745.1	ATP-binding protein	-
OO788_RS05440	1174104..1174874	+	771	WP_000450992.1	DUF1627 domain-containing protein	-
OO788_RS05445	1174890..1175303	+	414	WP_001151233.1	DUF977 family protein	-
OO788_RS05450	1175655..1176428	-	774	WP_000160654.1	alpha/beta hydrolase	-
-	1176963..1177021	-	59	-	-	Antitoxin
OO788_RS05460	1177033..1177188	+	156	WP_000813263.1	type I toxin-antitoxin system toxin HokD	Toxin
OO788_RS05465	1177356..1177634	+	279	WP_001341388.1	hypothetical protein	-
OO788_RS05470	1177636..1178685	+	1050	WP_001265172.1	DUF968 domain-containing protein	-
OO788_RS05475	1178698..1179069	+	372	WP_001217436.1	RusA family crossover junction endodeoxyribonuclease	-
OO788_RS05480	1179059..1179430	+	372	WP_000090264.1	antiterminator Q family protein	-
OO788_RS05485	1179582..1180400	+	819	WP_000265265.1	CPBP family intramembrane metalloprotease	-
OO788_RS05490	1180687..1180883	+	197	Protein_1075	TrmB family transcriptional regulator	-
OO788_RS05495	1181021..1181734	+	714	WP_000261909.1	helix-turn-helix domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 52 a.a.
• Molecular weight: 5722.86 Da
• Isoelectric Point: 6.1531

>T41954 WP_000813263.1 NZ_AP026090:1177033-1177188 [Escherichia coli]
MKQQKAMLIALIVICLTVIVTALVTRKDLCEVRVRTGQTEVAVFTAYEPEE

Nucleotide

• Length: 156 bp

>T41954 NZ_AP026090:1177033-1177188 [Escherichia coli]
ATGAAGCAGCAAAAGGCGATGTTAATCGCCCTGATCGTCATCTGTTTAACCGTCATAGTGACGGCACTGGTAACGAGGAA
AGACCTCTGCGAGGTACGAGTCCGAACCGGCCAGACGGAGGTCGCTGTCTTCACAGCTTACGAACCTGAGGAGTAA

Antitoxin

Nucleotide

• Length: 59 bp

>AT41954 NZ_AP026090:c1177021-1176963 [Escherichia coli]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTAGATTTGCCGTTCATAGATTGAGCCTCA

Structures

Antitoxin