41943

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) symE-agrB/SymE(toxin)
Location 5418743..5419155 Replicon chromosome
Accession NZ_AP026087
Organism Escherichia coli strain 8_140198

Toxin (Protein)


Gene name symE Uniprot ID Q8FA88
Locus tag OO841_RS27145 Protein ID WP_000132630.1
Coordinates 5418743..5419084 (-) Length 114 a.a.

Antitoxin (RNA)


Gene name agrB
Locus tag -
Coordinates 5419079..5419155 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OO841_RS28210 (5414311) 5414311..5414511 + 201 WP_001310455.1 hypothetical protein -
OO841_RS27125 (5414754) 5414754..5416166 - 1413 WP_000199295.1 PLP-dependent aminotransferase family protein -
OO841_RS27130 (5416343) 5416343..5416507 + 165 WP_000394274.1 DUF1127 domain-containing protein -
OO841_RS27135 (5416604) 5416604..5417485 + 882 WP_001304007.1 DUF262 domain-containing protein -
OO841_RS27140 (5417533) 5417533..5418696 + 1164 WP_001304006.1 DUF1524 domain-containing protein -
OO841_RS27145 (5418743) 5418743..5419084 - 342 WP_000132630.1 endoribonuclease SymE Toxin
- (5419079) 5419079..5419155 + 77 NuclAT_14 - Antitoxin
- (5419079) 5419079..5419155 + 77 NuclAT_14 - Antitoxin
- (5419079) 5419079..5419155 + 77 NuclAT_14 - Antitoxin
- (5419079) 5419079..5419155 + 77 NuclAT_14 - Antitoxin
- (5419079) 5419079..5419155 + 77 NuclAT_15 - Antitoxin
- (5419079) 5419079..5419155 + 77 NuclAT_15 - Antitoxin
- (5419079) 5419079..5419155 + 77 NuclAT_15 - Antitoxin
- (5419079) 5419079..5419155 + 77 NuclAT_15 - Antitoxin
OO841_RS27150 (5419305) 5419305..5421059 - 1755 WP_000110082.1 restriction endonuclease subunit S -
OO841_RS27155 (5421059) 5421059..5422528 - 1470 WP_001302468.1 type I restriction-modification system subunit M -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 5408236..5426956 18720


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(20-71)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12294.13 Da        Isoelectric Point: 8.4982

>T41943 WP_000132630.1 NZ_AP026087:c5419084-5418743 [Escherichia coli]
MTDTHSIAQPFEAEVSPANNRQLTVSYASRYPDYSRIPAITLKGQWLEAAGFATGTVVDVKVMEGCIVLTAQPPAAAESE
LMQSLRQVCKLSARKQRQVQEFIGVIAGKQKVA

Download         Length: 342 bp

>T41943 NZ_AP026087:c5419084-5418743 [Escherichia coli]
ATGACTGATACGCATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCCCCGGCAAATAACCGTCAATTAACCGTGAGTTA
TGCGAGTCGTTACCCGGATTACAGCCGTATTCCCGCCATCACCCTGAAAGGTCAGTGGCTGGAAGCCGCCGGTTTTGCCA
CCGGCACGGTGGTAGATGTCAAAGTGATGGAAGGCTGTATTGTCCTCACCGCCCAACCACCCGCCGCCGCCGAGAGCGAA
CTGATGCAGTCGCTGCGCCAGGTGTGCAAGCTGTCGGCGCGTAAACAAAGGCAGGTGCAGGAGTTTATTGGGGTGATTGC
GGGTAAACAGAAAGTTGCCTGA

Antitoxin


Download         Length: 77 bp

>AT41943 NZ_AP026087:5419079-5419155 [Escherichia coli]
AGTCATAACTGCTATTCCCTATAAATAGTGATTGTGATTAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y5T0

Antitoxin

Download structure file

References