Detailed information of TA system TA041845

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 2083021..2083246
• Replicon: chromosome
• Accession: NZ_AP026082
• Organism: Escherichia coli strain F765

Toxin (Protein)

• Gene name: hokW
• Uniprot ID: A0A1Q4PF16
• Locus tag: OO934_RS10290
• Protein ID: WP_000813258.1
• Coordinates: 2083021..2083176 (-)
• Length: 52 a.a.

Antitoxin (RNA)

Gene name	sokW
Locus tag	-
Coordinates	2083188..2083246 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
OO934_RS10240	2078024..2078455	-	432	WP_001302123.1	tellurite resistance protein	-
OO934_RS10255	2078906..2079619	-	714	WP_000301797.1	helix-turn-helix domain-containing protein	-
OO934_RS10260	2079755..2079952	-	198	WP_000917763.1	hypothetical protein	-
OO934_RS10265	2080177..2080731	-	555	WP_000640035.1	DUF1133 family protein	-
OO934_RS10270	2080794..2081099	-	306	WP_001217444.1	RusA family crossover junction endodeoxyribonuclease	-
OO934_RS10275	2081112..2082161	-	1050	WP_001265229.1	DUF968 domain-containing protein	-
OO934_RS10280	2082163..2082435	-	273	WP_000191871.1	hypothetical protein	-
OO934_RS10285	2082557..2082901	-	345	WP_000756596.1	YgiW/YdeI family stress tolerance OB fold protein	-
OO934_RS10290	2083021..2083176	-	156	WP_000813258.1	Hok/Gef family protein	Toxin
-	2083188..2083246	+	59	-	-	Antitoxin
OO934_RS10295	2083467..2084024	-	558	WP_000104474.1	DUF551 domain-containing protein	-
OO934_RS10300	2084026..2084244	-	219	WP_000683609.1	DUF4014 family protein	-
OO934_RS10305	2084372..2084683	-	312	WP_001289673.1	hypothetical protein	-
OO934_RS10310	2084676..2084903	-	228	WP_000699809.1	hypothetical protein	-
OO934_RS10315	2084900..2085181	-	282	WP_000603384.1	DNA-binding protein	-
OO934_RS10320	2085214..2085930	-	717	WP_000450627.1	DUF1627 domain-containing protein	-
OO934_RS10325	2085964..2086425	-	462	WP_000139447.1	replication protein P	-
OO934_RS10330	2086418..2087473	-	1056	WP_001356791.1	DnaT-like ssDNA-binding domain-containing protein	-
OO934_RS10335	2087542..2087967	-	426	WP_000693878.1	toxin YdaT family protein	-
OO934_RS10340	2087951..2088194	-	244	Protein_2031	Cro/CI family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	nleG7'	2045575..2150330	104755

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 52 a.a.
• Molecular weight: 5767.95 Da
• Isoelectric Point: 7.7942

>T41845 WP_000813258.1 NZ_AP026082:c2083176-2083021 [Escherichia coli]
MKQQKAMLIALIVICLTVIVTALVTRKDLCEVRIRTGQTEVAVFVDYESEK

Nucleotide

• Length: 156 bp

>T41845 NZ_AP026082:c2083176-2083021 [Escherichia coli]
ATGAAGCAGCAAAAGGCGATGTTAATCGCCCTGATCGTCATCTGTTTAACCGTCATAGTGACGGCACTGGTAACGAGGAA
AGACCTCTGCGAGGTGCGAATCCGAACCGGTCAGACGGAGGTCGCTGTCTTCGTAGACTACGAATCTGAGAAGTAA

Antitoxin

Nucleotide

• Length: 59 bp

>AT41845 NZ_AP026082:2083188-2083246 [Escherichia coli]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACATGTGTTCAGCATGGATTGAGCCTCA

Structures

Toxin

• AlphaFold DB: A0A1Q4PF16

Antitoxin