Detailed information of TA system TA041800

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 1179640..1179865
• Replicon: chromosome
• Accession: NZ_AP026080
• Organism: Escherichia coli strain F690

Toxin (Protein)

• Gene name: hokW
• Uniprot ID: -
• Locus tag: OO857_RS05475
• Protein ID: WP_000813263.1
• Coordinates: 1179710..1179865 (+)
• Length: 52 a.a.

Antitoxin (RNA)

Gene name	sokW
Locus tag	-
Coordinates	1179640..1179698 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
OO857_RS05445	1174914..1176005	+	1092	WP_001205823.1	hypothetical protein	-
OO857_RS05450	1176012..1176758	+	747	WP_000788745.1	ATP-binding protein	-
OO857_RS05455	1176780..1177550	+	771	WP_000450992.1	DUF1627 domain-containing protein	-
OO857_RS05460	1177566..1177979	+	414	WP_001151233.1	DUF977 family protein	-
OO857_RS05465	1178331..1179104	-	774	WP_000160654.1	alpha/beta hydrolase	-
-	1179640..1179698	-	59	-	-	Antitoxin
OO857_RS05475	1179710..1179865	+	156	WP_000813263.1	type I toxin-antitoxin system toxin HokD	Toxin
OO857_RS05480	1180033..1180311	+	279	WP_001341388.1	hypothetical protein	-
OO857_RS05485	1180313..1181362	+	1050	WP_001265172.1	DUF968 domain-containing protein	-
OO857_RS05490	1181375..1181746	+	372	WP_001217436.1	RusA family crossover junction endodeoxyribonuclease	-
OO857_RS05495	1181736..1182107	+	372	WP_000090264.1	antiterminator Q family protein	-
OO857_RS05500	1182259..1183077	+	819	WP_000265265.1	CPBP family intramembrane metalloprotease	-
OO857_RS05505	1183364..1183560	+	197	Protein_1078	TrmB family transcriptional regulator	-
OO857_RS05510	1183698..1184411	+	714	WP_000261909.1	helix-turn-helix domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 52 a.a.
• Molecular weight: 5722.86 Da
• Isoelectric Point: 6.1531

>T41800 WP_000813263.1 NZ_AP026080:1179710-1179865 [Escherichia coli]
MKQQKAMLIALIVICLTVIVTALVTRKDLCEVRVRTGQTEVAVFTAYEPEE

Nucleotide

• Length: 156 bp

>T41800 NZ_AP026080:1179710-1179865 [Escherichia coli]
ATGAAGCAGCAAAAGGCGATGTTAATCGCCCTGATCGTCATCTGTTTAACCGTCATAGTGACGGCACTGGTAACGAGGAA
AGACCTCTGCGAGGTACGAGTCCGAACCGGCCAGACGGAGGTCGCTGTCTTCACAGCTTACGAACCTGAGGAGTAA

Antitoxin

Nucleotide

• Length: 59 bp

>AT41800 NZ_AP026080:c1179698-1179640 [Escherichia coli]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTAGATTTGCCGTTCATAGATTGAGCCTCA

Structures

Antitoxin