Detailed information of TA system TA041791

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/Tad-HTH_37
• Location: 3092340..3092952
• Replicon: chromosome
• Accession: NZ_AP026075
• Organism: Acaryochloris marina MBIC10699

Toxin (Protein)

• Gene name: higB
• Uniprot ID: B0C629
• Locus tag: AM10699_RS13690
• Protein ID: WP_012166333.1
• Coordinates: 3092340..3092672 (+)
• Length: 111 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: AM10699_RS13695
• Protein ID: WP_012166334.1
• Coordinates: 3092662..3092952 (+)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AM10699_RS13670 (AM10699_27090)	3087535..3088377	-	843	WP_238549113.1	SDR family oxidoreductase	-
AM10699_RS13675 (AM10699_27100)	3088458..3088796	-	339	WP_261891558.1	DUF5367 domain-containing protein	-
AM10699_RS13680 (AM10699_27110)	3088978..3089985	-	1008	WP_012166331.1	tyrosine-type recombinase/integrase	-
AM10699_RS13685 (AM10699_27120)	3090231..3091334	+	1104	WP_261891523.1	potassium channel protein	-
AM10699_RS13690 (AM10699_27140)	3092340..3092672	+	333	WP_012166333.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
AM10699_RS13695 (AM10699_27150)	3092662..3092952	+	291	WP_012166334.1	helix-turn-helix transcriptional regulator	Antitoxin
AM10699_RS13705 (AM10699_27180)	3094182..3095177	-	996	WP_012166335.1	DUF3365 domain-containing protein	-
AM10699_RS34865 (AM10699_27190)	3095679..3097007	-	1329	WP_276552703.1	calcium-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	3070226..3092952	22726

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (16-103)

Antitoxin

• Cro/C1-type helix-turn-helix domain (35-89)

Sequences

Toxin

Protein

• Length: 111 a.a.
• Molecular weight: 12742.93 Da
• Isoelectric Point: 9.8173

>T41791 WP_012166333.1 NZ_AP026075:3092340-3092672 [Acaryochloris marina MBIC10699]
MAWSVQYYSETVESEVLALPPGLLARYLRLTDLMLEFGPNLGMPHTQSMGDRLFELRVKSKEGIARVFYCTLIGERIVML
HSFVKKTQKTPNRELKIARRRLKEVIDNDS

Nucleotide

• Length: 333 bp

>T41791 NZ_AP026075:3092340-3092672 [Acaryochloris marina MBIC10699]
ATGGCCTGGAGTGTTCAATATTATTCCGAAACAGTTGAATCTGAGGTACTTGCTCTGCCTCCAGGTTTGTTAGCTAGATA
TTTGAGGCTCACCGACCTCATGTTAGAGTTTGGTCCCAATCTGGGGATGCCTCACACCCAATCCATGGGCGATCGCCTAT
TTGAATTGAGGGTAAAGAGCAAGGAAGGGATTGCGAGGGTGTTTTATTGCACCCTGATCGGCGAAAGGATAGTGATGCTG
CACAGCTTTGTGAAGAAGACTCAAAAGACCCCCAATCGTGAACTCAAGATCGCGCGTCGTCGGTTAAAAGAGGTGATAGA
CAATGACTCATGA

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10587.10 Da
• Isoelectric Point: 7.1668

>AT41791 WP_012166334.1 NZ_AP026075:3092662-3092952 [Acaryochloris marina MBIC10699]
MTHEDLKAKALNNPEVAEEYEKLEEEFSLLRQMLAARQNAGLTQADIAEKMGTKATAVTRLESSLSSGKHSPSLSTLRKY
AKAVGCRLEVKLVPEQ

Nucleotide

• Length: 291 bp

>AT41791 NZ_AP026075:3092662-3092952 [Acaryochloris marina MBIC10699]
ATGACTCATGAGGATCTCAAAGCAAAAGCCCTAAACAATCCAGAAGTGGCTGAAGAGTACGAAAAACTAGAGGAAGAGTT
TAGTCTTTTAAGGCAAATGCTTGCTGCCCGCCAGAATGCAGGTCTAACTCAAGCTGACATTGCTGAAAAAATGGGGACAA
AGGCAACAGCAGTGACCCGGCTGGAATCATCCCTCAGTAGTGGTAAGCATTCACCATCCCTATCCACTTTGCGAAAGTAT
GCCAAGGCAGTGGGTTGCCGTTTAGAAGTGAAGTTAGTGCCAGAACAGTAG

Structures

Toxin

• AlphaFold DB: B0C629