Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2843984..2844587 Replicon chromosome
Accession NZ_AP026075
Organism Acaryochloris marina MBIC10699

Toxin (Protein)


Gene name graT Uniprot ID -
Locus tag AM10699_RS12555 Protein ID WP_041660594.1
Coordinates 2843984..2844268 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag AM10699_RS12560 Protein ID WP_012166089.1
Coordinates 2844276..2844587 (+) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AM10699_RS12530 (AM10699_24910) 2839890..2840771 - 882 WP_012166083.1 inositol monophosphatase family protein -
AM10699_RS12535 (AM10699_24920) 2840857..2842602 + 1746 WP_012166084.1 ABC transporter ATP-binding protein/permease -
AM10699_RS12540 (AM10699_24930) 2842707..2843045 + 339 WP_012166085.1 hypothetical protein -
AM10699_RS12545 (AM10699_24940) 2843078..2843299 + 222 WP_012166086.1 N-acetyltransferase -
AM10699_RS12550 (AM10699_24950) 2843561..2843863 + 303 WP_041660592.1 hypothetical protein -
AM10699_RS12555 (AM10699_24960) 2843984..2844268 + 285 WP_041660594.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
AM10699_RS12560 (AM10699_24970) 2844276..2844587 + 312 WP_012166089.1 HigA family addiction module antitoxin Antitoxin
AM10699_RS12565 (AM10699_24980) 2844664..2845149 - 486 WP_012166090.1 hypothetical protein -
AM10699_RS12570 (AM10699_24990) 2845343..2845582 - 240 WP_238549095.1 thioredoxin family protein -
AM10699_RS12575 (AM10699_25000) 2845730..2846050 + 321 WP_261891487.1 helix-turn-helix domain-containing protein -
AM10699_RS12580 (AM10699_25010) 2846511..2846801 + 291 WP_261891488.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(13-94)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(9-84)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10902.54 Da        Isoelectric Point: 9.4238

>T41790 WP_041660594.1 NZ_AP026075:2843984-2844268 [Acaryochloris marina MBIC10699]
MIVRFSSKETKLIFYGYTSRVYPPDIQKIALRKLLILDAAASVDDLRIPPGNRLEKLAGDRKGQYSIRINSQWRICFTWT
AENNADQVEIVDYH

Download         Length: 285 bp

>T41790 NZ_AP026075:2843984-2844268 [Acaryochloris marina MBIC10699]
ATGATAGTAAGGTTTAGCTCCAAAGAAACGAAGCTTATCTTCTATGGCTACACATCTCGTGTATATCCACCTGATATCCA
AAAGATTGCGTTACGCAAACTCCTCATACTTGATGCCGCGGCATCAGTGGATGATTTGCGTATTCCTCCAGGAAATCGAT
TAGAGAAGCTAGCGGGAGATCGTAAAGGACAATACAGCATCCGTATCAATAGCCAATGGCGAATCTGCTTTACCTGGACA
GCAGAAAATAATGCCGATCAAGTTGAAATCGTTGATTACCATTGA

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 11656.28 Da        Isoelectric Point: 7.2000

>AT41790 WP_012166089.1 NZ_AP026075:2844276-2844587 [Acaryochloris marina MBIC10699]
MENGRLPIIHPGEILKLEFLEPLDLTPYRLSKDIGVAQTRISEILSGKRSITADTALRLSQYFGNSAQFWLNLQTQYDLR
QAQEANRGVYSQIPTIQLAHLSS

Download         Length: 312 bp

>AT41790 NZ_AP026075:2844276-2844587 [Acaryochloris marina MBIC10699]
ATGGAAAACGGTCGTCTGCCAATTATTCACCCTGGAGAAATCTTAAAACTAGAGTTTCTTGAGCCGCTGGATCTCACGCC
ATATCGTTTAAGTAAGGATATTGGTGTTGCTCAAACCAGAATTAGCGAAATATTGTCTGGGAAGCGTAGTATTACTGCTG
ATACAGCCCTTCGTCTATCTCAGTATTTTGGCAACAGCGCTCAATTCTGGTTGAACTTACAGACACAATATGATTTACGC
CAAGCTCAGGAAGCCAATAGAGGTGTATACAGCCAAATTCCAACCATACAACTTGCTCACCTGTCATCCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References