Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 1527819..1528331 Replicon chromosome
Accession NZ_AP025939
Organism Streptococcus pneumoniae strain Utah_35B-24

Toxin (Protein)


Gene name yoeB Uniprot ID A0A6I3U3U7
Locus tag QMM27_RS07580 Protein ID WP_000924720.1
Coordinates 1527819..1528073 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID K0ZY22
Locus tag QMM27_RS07585 Protein ID WP_000388572.1
Coordinates 1528077..1528331 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QMM27_RS07565 (Utah35B_15020) 1524920..1525234 - 315 WP_000979235.1 DNA-directed RNA polymerase subunit omega -
QMM27_RS07570 (Utah35B_15030) 1525259..1525885 - 627 WP_000775044.1 guanylate kinase -
QMM27_RS07575 (Utah35B_15040) 1526015..1527628 - 1614 WP_000404940.1 ribonuclease Y -
QMM27_RS07580 (Utah35B_15050) 1527819..1528073 - 255 WP_000924720.1 Txe/YoeB family addiction module toxin Toxin
QMM27_RS07585 (Utah35B_15060) 1528077..1528331 - 255 WP_000388572.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
QMM27_RS07590 (Utah35B_15070) 1528569..1529666 - 1098 WP_000156361.1 nucleotidyltransferase -
QMM27_RS07595 (Utah35B_15080) 1529676..1530416 - 741 WP_000257069.1 class I SAM-dependent methyltransferase -
QMM27_RS07600 (Utah35B_15090) 1530525..1530878 - 354 WP_001003001.1 ribosome silencing factor -
QMM27_RS07605 (Utah35B_15100) 1530891..1531391 - 501 WP_000844707.1 cysteine hydrolase family protein -
QMM27_RS07610 (Utah35B_15110) 1531392..1531985 - 594 WP_000121653.1 bis(5'-nucleosyl)-tetraphosphatase (symmetrical) YqeK -
QMM27_RS07615 (Utah35B_15120) 1531985..1532614 - 630 WP_000151307.1 nicotinate-nucleotide adenylyltransferase -
QMM27_RS07620 (Utah35B_15130) 1532666..1532977 - 312 WP_000060169.1 ribosome assembly RNA-binding protein YhbY -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(1-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-75)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10032.48 Da        Isoelectric Point: 7.8087

>T41778 WP_000924720.1 NZ_AP025939:c1528073-1527819 [Streptococcus pneumoniae]
MLLKFTEDAWADYCYWQNQDKKTLKRINKLIKDIQRDPFTGIGKPEPLKYDYQGACSRRIDAENRLIYMMDGDSVAFLSF
KDHY

Download         Length: 255 bp

>T41778 NZ_AP025939:c1528073-1527819 [Streptococcus pneumoniae]
ATGCTGCTCAAGTTTACAGAAGATGCCTGGGCAGATTATTGCTACTGGCAAAATCAGGATAAGAAAACGTTAAAAAGAAT
CAATAAACTAATCAAGGATATTCAACGTGATCCCTTTACAGGAATAGGTAAACCAGAACCACTCAAGTATGACTACCAAG
GAGCTTGCTCACGTCGTATTGATGCAGAAAATCGCTTGATTTATATGATGGATGGAGATAGCGTGGCTTTCTTGTCCTTT
AAAGATCATTACTAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9706.00 Da        Isoelectric Point: 4.8430

>AT41778 WP_000388572.1 NZ_AP025939:c1528331-1528077 [Streptococcus pneumoniae]
MEAVLYSTFRNHLKDYMKKVNDEFEPLTVVNKNPDEDIVVLSKSEWDSIQETLRIAQNKELSDKVLRGMAQVRAGSTQVH
VIEE

Download         Length: 255 bp

>AT41778 NZ_AP025939:c1528331-1528077 [Streptococcus pneumoniae]
ATGGAAGCAGTCCTTTACTCAACATTCCGAAATCATTTAAAGGACTACATGAAGAAGGTAAATGATGAATTTGAGCCTTT
GACGGTGGTCAATAAAAATCCAGACGAGGACATTGTAGTCCTTTCAAAGAGTGAGTGGGATAGTATCCAAGAAACCCTGA
GAATTGCTCAAAATAAGGAACTTTCTGATAAGGTTTTGCGAGGAATGGCTCAAGTTCGTGCTGGAAGTACTCAGGTCCAT
GTTATTGAGGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6I3U3U7

Antitoxin

Source ID Structure
AlphaFold DB K0ZY22

References