Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 1527800..1528312 Replicon chromosome
Accession NZ_AP025937
Organism Streptococcus pneumoniae strain PZ900700792

Toxin (Protein)


Gene name yoeB Uniprot ID A0A6I3U3U7
Locus tag QML92_RS07565 Protein ID WP_000924720.1
Coordinates 1527800..1528054 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID K0ZY22
Locus tag QML92_RS07570 Protein ID WP_000388572.1
Coordinates 1528058..1528312 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QML92_RS07550 (PC0780_15040) 1524901..1525215 - 315 WP_000979235.1 DNA-directed RNA polymerase subunit omega -
QML92_RS07555 (PC0780_15050) 1525240..1525866 - 627 WP_000775044.1 guanylate kinase -
QML92_RS07560 (PC0780_15060) 1525996..1527609 - 1614 WP_000404940.1 ribonuclease Y -
QML92_RS07565 (PC0780_15070) 1527800..1528054 - 255 WP_000924720.1 Txe/YoeB family addiction module toxin Toxin
QML92_RS07570 (PC0780_15080) 1528058..1528312 - 255 WP_000388572.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
QML92_RS07575 (PC0780_15090) 1528550..1529647 - 1098 WP_000156361.1 nucleotidyltransferase -
QML92_RS07580 (PC0780_15100) 1529657..1530397 - 741 WP_000257069.1 class I SAM-dependent methyltransferase -
QML92_RS07585 (PC0780_15110) 1530506..1530859 - 354 WP_001003001.1 ribosome silencing factor -
QML92_RS07590 (PC0780_15120) 1530872..1531372 - 501 WP_000844707.1 cysteine hydrolase family protein -
QML92_RS07595 (PC0780_15130) 1531373..1531966 - 594 WP_000121653.1 bis(5'-nucleosyl)-tetraphosphatase (symmetrical) YqeK -
QML92_RS07600 (PC0780_15140) 1531966..1532595 - 630 WP_000151307.1 nicotinate-nucleotide adenylyltransferase -
QML92_RS07605 (PC0780_15150) 1532647..1532958 - 312 WP_000060169.1 ribosome assembly RNA-binding protein YhbY -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(1-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-75)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10032.48 Da        Isoelectric Point: 7.8087

>T41771 WP_000924720.1 NZ_AP025937:c1528054-1527800 [Streptococcus pneumoniae]
MLLKFTEDAWADYCYWQNQDKKTLKRINKLIKDIQRDPFTGIGKPEPLKYDYQGACSRRIDAENRLIYMMDGDSVAFLSF
KDHY

Download         Length: 255 bp

>T41771 NZ_AP025937:c1528054-1527800 [Streptococcus pneumoniae]
ATGCTGCTCAAGTTTACAGAAGATGCCTGGGCAGATTATTGCTACTGGCAAAATCAGGATAAGAAAACGTTAAAAAGAAT
CAATAAACTAATCAAGGATATTCAACGTGATCCCTTTACAGGAATAGGTAAACCAGAACCACTCAAGTATGACTACCAAG
GAGCTTGCTCACGTCGTATTGATGCAGAAAATCGCTTGATTTATATGATGGATGGAGATAGCGTGGCTTTCTTGTCCTTT
AAAGATCATTACTAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9706.00 Da        Isoelectric Point: 4.8430

>AT41771 WP_000388572.1 NZ_AP025937:c1528312-1528058 [Streptococcus pneumoniae]
MEAVLYSTFRNHLKDYMKKVNDEFEPLTVVNKNPDEDIVVLSKSEWDSIQETLRIAQNKELSDKVLRGMAQVRAGSTQVH
VIEE

Download         Length: 255 bp

>AT41771 NZ_AP025937:c1528312-1528058 [Streptococcus pneumoniae]
ATGGAAGCAGTCCTTTACTCAACATTCCGAAATCATTTAAAGGACTACATGAAGAAGGTAAATGATGAATTTGAGCCTTT
GACGGTGGTCAATAAAAATCCAGACGAGGACATTGTAGTCCTTTCAAAGAGTGAGTGGGATAGTATCCAAGAAACCCTGA
GAATTGCTCAAAATAAGGAACTTTCTGATAAGGTTTTGCGAGGAATGGCTCAAGTTCGTGCTGGAAGTACTCAGGTCCAT
GTTATTGAGGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6I3U3U7

Antitoxin

Source ID Structure
AlphaFold DB K0ZY22

References