Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 3857745..3858420 Replicon chromosome
Accession NZ_AP025903
Organism Enterobacter hormaechei strain FUJ80374

Toxin (Protein)


Gene name higB Uniprot ID A0A837FDC1
Locus tag NGK42_RS18625 Protein ID WP_015571638.1
Coordinates 3857745..3858044 (+) Length 100 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A2J0PXC9
Locus tag NGK42_RS18630 Protein ID WP_015571639.1
Coordinates 3858055..3858420 (+) Length 122 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NGK42_RS18615 (FJMB80374_36580) 3854122..3856314 + 2193 WP_032649255.1 type I secretion system permease/ATPase -
NGK42_RS18620 (FJMB80374_36590) 3856295..3857494 + 1200 WP_017382757.1 HlyD family efflux transporter periplasmic adaptor subunit -
NGK42_RS18625 3857745..3858044 + 300 WP_015571638.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NGK42_RS18630 (FJMB80374_36600) 3858055..3858420 + 366 WP_015571639.1 HigA family addiction module antitoxin Antitoxin
NGK42_RS18635 (FJMB80374_36610) 3858447..3859628 - 1182 WP_017382758.1 PLP-dependent aminotransferase family protein -
NGK42_RS18640 (FJMB80374_36620) 3859649..3860536 - 888 WP_015571641.1 LysR family transcriptional regulator -
NGK42_RS18645 (FJMB80374_36630) 3860634..3861236 + 603 WP_017382759.1 short chain dehydrogenase -
NGK42_RS18650 (FJMB80374_36640) 3861347..3862726 - 1380 WP_032649259.1 amidohydrolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(25-72)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11624.29 Da        Isoelectric Point: 9.6776

>T41627 WP_015571638.1 NZ_AP025903:3857745-3858044 [Enterobacter hormaechei]
MINHFRDQWLEDFFLYGRSSNVIPLNLETALARKLDIINAAMSHLDLRSPPGNMYEALSPPLKGYSSIRVNRQYRLVFRW
SEGKADDLYLSPHKYTQHK

Download         Length: 300 bp

>T41627 NZ_AP025903:3857745-3858044 [Enterobacter hormaechei]
ATGATTAATCATTTTCGGGATCAATGGCTTGAGGATTTTTTTCTCTACGGGAGATCGAGCAATGTTATTCCTTTGAATCT
GGAAACAGCGCTTGCAAGAAAGCTCGACATCATCAATGCGGCCATGTCGCACCTGGATTTACGATCGCCACCGGGCAATA
TGTATGAAGCATTGAGTCCTCCGTTGAAGGGATATTCCTCTATCCGGGTAAACAGACAATACAGGCTTGTATTTCGCTGG
TCAGAGGGAAAAGCAGACGATCTCTATCTCTCTCCACACAAGTACACGCAACACAAGTGA

Antitoxin


Download         Length: 122 a.a.        Molecular weight: 13705.73 Da        Isoelectric Point: 9.5936

>AT41627 WP_015571639.1 NZ_AP025903:3858055-3858420 [Enterobacter hormaechei]
MTLQQALRKPTTPGEVLQYEYLEPLNLKINDLAEMLNVHRNTVSALVNNNRKLTADMAIKLAKAFNTTIEFWLNLQLNVD
IWEAQSNSRTQEELSRIKTVAEVMAKRKSGKPDVTLHGNSA

Download         Length: 366 bp

>AT41627 NZ_AP025903:3858055-3858420 [Enterobacter hormaechei]
ATGACACTTCAACAGGCACTCCGCAAACCCACCACGCCGGGCGAGGTGTTGCAGTATGAGTATCTTGAACCGCTCAATCT
GAAAATCAACGATCTGGCAGAGATGCTAAATGTACACCGCAATACCGTAAGCGCGTTGGTCAATAACAATCGCAAACTTA
CTGCCGATATGGCGATCAAACTGGCAAAAGCCTTTAATACCACTATTGAATTTTGGCTGAACTTACAGCTAAACGTTGAT
ATCTGGGAAGCGCAATCTAACTCCCGCACGCAGGAGGAGTTAAGCCGGATAAAAACCGTTGCGGAAGTCATGGCGAAGCG
AAAATCCGGCAAGCCAGACGTTACCCTGCACGGGAACAGCGCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A837FDC1

Antitoxin

Source ID Structure
AlphaFold DB A0A2J0PXC9

References